IndraLab

Statements

reach
"ROS scavengers blocked shikonin induced inactivation of Akt and RIP1 and NF-kappaB, but Akt or RIP1 and NF-kappaB did not regulate ROS generation, suggesting that Akt and RIP1 and NF-kappaB signals are downstream of ROS generation."
22011623
reach
"In addition, ROS scavenger (N-acetyl-L-cysteine, NAC) and NOX4 inhibitor GKT137831 reduced ROS generation and alleviated activation of Xbp1 and RIPK1 related NF-kappaB signaling."
27929749
reach
"It has been reported that ROS promotes necroptosis by a positive feedback mechanism in osteoblastic cells, while ROS inhibitor N-acetylcysteine (NAC) attenuates the up-regulation of RIPK1, RIPK3 and MLKL, and the RIP1 inhibitor necrostatin-1 (Nec-1) reduced ROS generation [17]."
33350608