IndraLab

Statements


YOD1 inhibits pr1. 1 / 1
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"Similarly, co-expression with the dominant negative mammalian deubiquitinylase YOD1 (YOD1-C160S) [37] or the dominant negative mutant of the AAA p97 ATPase, which lacks ATPase activity (p97QQ, E305 and E578 mutated into Q) [38], blocked degradation of pr1 from construct 2A*, which accumulated intracellularly further confirming degradation through the ubiquitin–proteasome pathway (Fig. 5e)."