IndraLab

Statements

SRC phosphorylated on Y419 is kinase-active. 9 / 9
9 |
bel
"Ox-PAPC and its component phospholipids induced a rapid and transient phosphorylation of c-src Tyr418, a hallmark of c-src activation, in human aortic endothelial cells (HAEC)."
15143062
bel
"Here we show that EphB stimulates a metalloproteinase cleavage of ephrinB2, producing a carboxy-terminal fragment that is further processed by PS1/gamma-secretase to produce intracellular peptide ephrinB2/CTF2. This peptide binds Src and inhibits its association with inhibitory kinase Csk, allowing autophosphorylation of Src at residue tyr418."
16511561
bel
"The autophosphorylation and dephosphorylation of Y419 are directly correlated with the level of src TK activity."
8755732
bel
"In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways."
bel
"ESULTS: TUDC induced a rapid activation of focal adhesion kinase (FAK) and Src, as shown by an increase in Y418 phosphorylation and a decrease in Y529 phosphorylation of Src."
12730886
bel
"Bacterially expressed wild-type PTP-BL phosphatase domain, but not a cata-lytically inactive point mutant of PTP-BL (PTP-BL-CS), dephosphorylated Src specifically on Y418, a tyrosine autophosphorylation site required for Src activation (re-viewed in Bjorge et al., 2000)."
11983165
bel
"In cells expressing RPTPkappa RNAi, phosphorylation of Src at Tyr527 was increased and (activating) phosphorylation of Src at Tyr416 was reduced."
15899872
bel
"The chief phosphorylation sites of Src include tyrosine 416 that results in activation from autophosphorylation and tyrosine 527 that results in inhibition from phosphorylation by C-terminal Src kinase"
15504335
bel
"In parallel to activation, autophosphorylation at Tyr-416 of Src kinase increased Aldosterone led to increased association of Src with HSP84"
15251441