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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Lipopolysaccharide bound to CD14 receptor activates JNK. 1 / 1

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"LPS, the active component of endotoxins, interacts with LPS binding protein and the CD14 receptor, activating TLRs and, consequently, the inflammatory cascade that involves stress activated protein kinases, JNK, p38, interferon regulatory factor-3 (IRF-3) and NF-kappaB, pathways implicated in insulin resistance and triglycerides synthesis [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...