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IL6 phosphorylates STAT3 on Y705. 166 / 167
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"IL-6 activates the JAK and STAT signaling pathway and leads to phosphorylation of Tyr 705 of the STAT3 protein [XREF_BIBR]."
22236378
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"Next, to determine if STAT3 activation is sufficient to induce FTO-regulated ISGs, we treated Huh7 cells with IL-6, which induces Y705 phosphorylation of STAT3 [30]."
34537236
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"The IL-6 induced constitutive phosphorylation of STAT3 Y705 was effectively suppressed by raloxifene in a dose-dependent manner (Fig.  xref b)."
32940862
sparser
"Pretreatment of ECs with Mag dose dependently inhibited IL-6-induced Tyr705 and Ser727 phosphorylation in STAT3 without affecting the phosphorylation of JAK1, JAK2, and ERK1/2."
16520748
sparser
"Hence, IL-6 is generally known to activate JAK/STAT3 pathway regardless of binding to soluble or membrane bound IL-6R. In line with this, we show that both classic- and trans-signaling of IL-6 trigger STAT3 Tyr705 phosphorylation in a dose- and time-dependent manner."
30185178
sparser
"When HepG2 cells were held at 15 °C, the rate of IL-6 induced STAT3 Y705 phosphorylation was noticeably delayed ( xref )."
21619877
sparser
"Even more surprisingly, the co-treatment of VD3 and IL6 induced significant phosphorylation of STAT3 Tyr705 at 24 h post-treatment that was not induced by the single treatments ( xref )."
33618332
sparser
"Phosphorylation at Tyr705 in STAT3 is induced by IL-6 and IL-23, involves the PI3K-Akt-mTORC1 pathway and controls Th17 commitment and function ( xref , xref )."
29237778
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"Studies have shown that IL-6 induces STAT3 phosphorylation on both Tyr705 and Ser727 [XREF_BIBR, XREF_BIBR]."
27074565
sparser
"STATTIC (80 μM), a small molecule inhibitor that binds the STAT3 SH2 domain to inhibit phosphorylation [ xref ], abolished IL-6 induced STAT3 Y705 phosphorylation following IL-6 treatment ( xref )."
21619877
sparser
"IL-6 induced phosphorylation of STAT3 at both Tyr705 and Ser727 (Fig. xref and xref )."
26417930
sparser
"We found that B6 had dose-dependent but differential inhibitory effects on the IL-6-induced STAT3 Tyr705 phosphorylation, IFN-γ-induced STAT1 Tyr701 phosphorylation (Fig.  xref ) and IFN-α-induced phosphorylation of both STAT1 and STAT3 (Fig.  xref ), which was consistent with the luciferase assay results."
31201357
sparser
"TGR5 activation by both 23(S)-mCDCA and GPBARA suppresses IL-6-induced phosphorylation of STAT3 at Tyr705 by about 36% and 38%, respectively (Fig. xref ), but not at Ser727 ( xref )."
26417930
sparser
"We found that IL-6 induced STAT3 phosphorylation at Y705, the STAT3 phospho-activation site, but not at S727 (the other site for transcriptional activation in STAT3) ( xref a–c)."
29270528
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"In cardiac myocytes, IL-6 treatment increases phosphorylation of STAT3 at the Tyr705 through the enhanced de novo synthesis of iNOS protein, leading to increased NO production and decreased cardiac contractility [XREF_BIBR]."
27995459
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"In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues."
28722170
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"IL-6 derived from PTFs greatly activated STAT3 Tyr705 phosphorylation in both non tumor L-02 cells and HCC cells."
31118769
sparser
"Analogously, culture of OPM2 cells with CM or IL-6 sharply increased STAT3 Y705 phosphorylation but had lesser effects on S727 ( xref , xref )."
34782371
sparser
"Mechanisms that reduce IL-6-induced STAT3-Y705 phosphorylation such as expression of SOCS3 and STAT3-S727 phosphorylation on the one hand increase robustness of signalling against varying STAT3 expression."
| PMC
sparser
"As shown, C188-9 dose-dependently inhibited the IL-6-induced phosphorylation of STAT3 at the Y705 ( xref )."
29410184
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"Further report dictated that mesenchymal stem cells, present in bone marrow, promote bone metastasis of ER positive breast cancer cells through IL-6 dependent phosphorylation of STAT3 at Tyr705 positi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26945971
sparser
"In this study, phosphorylation of STAT3 at Y705 induced by IL-6 was weakly inhibited by AG490, a Jak2 kinase inhibitor, but not by cirsiliol at 90 μM in the serum-starved condition ( xref )."
33392396
sparser
"At 48 h after transfection, exposure of exogenous IL-6 in scrambled siRNA-transfected A549 cells induced tyrosine 705 phosphorylation in a dose-dependent manner, and IL-6-induced STAT3 Tyr705 phospho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23583378
reach
"Phosphorylation of STAT3 at Tyr705 induced by IL-6 is inhibited by sorafenib."
20371721
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"Knockdown of STAT3 in human vascular endothelial cells using siRNA (knockdown efficiency 80-90%) abolished the phosphorylation of STAT3 Tyr705 caused by IL-6 trans-signaling."
30185178
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"Further experiment revealed that the IL-6 and STAT3 pathway was diminished in the resistant cell lines (XREF_FIG), as exogenous IL-6 induced less STAT3 Tyr705 phosphorylation in the cisplatin resistant than in the cisplatin- sensitive parental cell lines."
27108527
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"It has been shown that IL-6-induced JAK-STAT3 signaling pathway activation plays important roles in endothelial cell activation [ xref ] that is mainly mediated by IL-6-induced Tyr705 phosphorylation in STAT3 [ xref ], which resembles our data on B7-H4 regulation by GM-CSF-induced Tyr705 phosphorylation of STAT3 in neutrophils."
33763491
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"In the present investigation, we sought to determine for the first time the significance of STAT-3 phosphorylation on tyrosine 705, which is described to be transiently induced by IL-6 in CLL cells [XREF_BIBR]."
24883303
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"ALT inhibits IL-6-induced STAT3 tyrosine 705 phosphorylation."
33828598
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"To assess whether sunitinib also inhibits the phosphorylation of STAT3 at Tyr705 induced by IL-6, tumor cells were treated with sunitinib for 20 min, followed by the addition of IL-6 (10 ng/ml) for 10 min."
20053726
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"These results demonstrate that activation of FGFR1 leads to production of IL-6 family cytokines, which act through gp130 to induce phosphorylation of STAT3 Tyr705."
24197137
sparser
"In LNCaP cells where Stat3 is not constitutively active, exogenous addition of IL-6 induced phosphorylation of Stat3 at Tyr705, which was reduced by sanguinarine ( xref )."
21538419
bel
"Phosphorylation of a tyrosine residue at 705 in STAT3 is observed in KMS-11 in response to IL-6. In contrast, bFGF induces the activation of ERK1/2 and PI-3 kinase. These results indicate that IL-6 and bFGF activate the distinct intra- cellular signaling pathways, and both the ERK1/2 and PI-3 kinase pathways activated by bFGF are necessary for the enhanced proliferation of KMS-11. "
17142955
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"In most HCC cell lines, IL-6 enhances STAT3-Y705 phosphorylation."
30606233
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"CPT or a STAT3 siRNA significantly suppressed constitutive and IL-6-induced phosphorylation of STAT3 Tyr705, decreasing the levels of proteins encoded by STAT3-target genes (Bcl-xL, Mcl-1, survivin, and XIAP)."
28222632
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"In this study, we confirmed that IL-6 could phosphorylate STAT3 (Y705) (XREF_FIG) but this induction was inhibited by HHT treatment (XREF_FIG) and the STAT3 nucleus translocation and transcription activity were simultaneously repressed (XREF_FIG)."
26166037
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"As can be seen in XREF_FIG, niclosamide inhibited interleukin 6 induced phosphorylation of STAT3 Y705 phosphorylation in a dose dependent manner with 2mu completely inhibiting detection of phosphorylated Y705."
22829072
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"It has been shown previously that IL-6 stimulation leads to STAT3 phosphorylation at Tyrosine 705 (Y705) and Serine 727 (S727) which have been suggested to be required for dimerization and maximal transcriptional activity of STAT3."
27311882
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"CPT inhibits interleukin 6 (IL6)-induced phosphorylation of STAT3 Tyr705 in gastric cancer cells."
28222632
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"IL-6 strongly induced STAT3 phosphorylation at Y705 but not S727 and was inhibited by WFA after only 2 hours of incubation (XREF_FIG); however, total STAT3 levels were reduced after exposure of cells to WFA for more than 4 hours, suggesting that WFA also downregulates STAT3 protein if cells are exposed to the drug for longer time periods."
25452693
sparser
"DDIAS depletion attenuated IL-6–induced STAT3 phosphorylation at Y705 but not at S727 in non-small cell lung cancer (NSCLC) cells, such as NCI-H23 and NCI-H1703 (Fig. xref )."
31900385
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"IL-6 overexpression is also commonly observed in GBs and demonstrated to induce STAT3 phosphorylation at Tyr-705 through the hexameric receptor complex IL-6Rα binding [10,36]."
31698775
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"The activation of numerous cytokines and molecules like the anti-inflammatory IL-10, proinflammatory interferon (IFN), interleukin-6 (IL-6), and lipopolysaccharide (LPS), can phosphorylate STAT3 at Tyr705 and induce dimerization and nuclear translocation of STAT3."
31803051
rlimsp
"In this study, we confirmed that IL-6 could phosphorylate STAT3 (Y705) (Fig. 4B) but this induction was inhibited by HHT treatment (Fig. 4C) and the STAT3 nucleus translocation and transcription activity were simultaneously repressed (Fig. 4D–F)."
26166037
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"In BAEC, pretreatment for 30 min with the arachidonic acid metabolite and electrophile, 15-deoxy- Δ 12,14 –prostaglandin J 2 (15d-PGJ 2 ) inhibited IL-6-induced STAT3 Y705 phosphorylation, as did acrolein xref ."
22905257
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"IL-6 rapidly activated STAT3 (Y705) phosphorylation within 15 min (XREF_FIG), corresponding to an acute rise in STAT3 genes IL-6 and SOCS3 (XREF_FIG)."
22698915
sparser
"As shown in xref A,B, the result demonstrated that BBM not only dose-dependently suppressed the phosphorylation of STAT3 at tyrosine 705 (Y705) induced by IL-6 but also decreased the nuclear translocation of STAT3."
33015502
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"When applied together with sIL-6R, very low concentrations of IL-6 (i.e. 1ng/ml) were sufficient to induce STAT3 Tyr705 phosphorylation (Additional file 3 : Figure S3), while higher concentrations (i.e. 50ng/ml) were required to induce similar degree of phosphorylation when IL-6 is added without sIL-6R."
30185178
reach
"Even more surprisingly, the co-treatment of VD3 and IL6 induced significant phosphorylation of STAT3 Tyr705 at 24 h post-treatment that was not induced by the single treatments (XREF_FIG)."
33618332
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"Because IL-6 is an activator of the JAK2 and STAT3 signaling pathway, exogenous IL-6 was used to induce the phosphorylation of STAT3 at Tyr705."
26580615
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"IL-6 increases STAT3 activation by phosphorylating STAT3 on tyrosine 705 and/or serine 727 in a broad range of human malignancies at the probability of 50% to 90% (Jiang et al., 2011; Wang et al., 201[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26101800
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"Further analysis of the mechanisms driving STAT3 phosphorylation demonstrated that FGFR activation induces various IL-6 family members, which contributed to phosphorylation of STAT3 Tyr705."
24197137
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"Stattic inhibited IL-6−induced STAT3 phosphorylation at Y705 in a dose-dependent manner in PBMC- and tonsil-derived cells from IgAN patients and in those from the control subjects ( xref c and d; xref c and d)."
29270528
reach
"In serum-free medium, recombinant IL-6 and the IL-6-rich IRISOE TNBC cell condition media (CM) decreased STAT3 Y705 phosphorylation (p-STAT3 Y705) in MSCs."
31014367
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"IL-6 treatment (150 ng/ml, 30 min) of cultured epididymal adipose tissue (eWAT) led to an ~ 3-fold increase in the tyrosine 705 phosphorylation of STAT3."
22844518
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"These observations led us to the overarching hypothesis that negative regulation increases robustness of IL-6-induced STAT3-Y705 phosphorylation against varying STAT3 expression in individual cells."
| PMC
sparser
"In all three lines, exogenous addition of IL-6 induced phosphorylation of Stat3 Tyr705 ( xref ), which was inhibited following treatment with AZD1480."
19962667
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"Our results showed that IL-6 stimulated STAT3 phosphorylation on tyrosine 705 in DLD1 and Hep3B cancer cells."
26883202
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"IL-6 leads to phosphorylation of STAT3 at tyrosine 705 and its subsequent activation and nuclear translocation via serine 727 phosphorylation."
22079905
sparser
"As shown in xref , treatment of DU145 cells with sanguinarine resulted in a significant decrease in the levels of both constitutive and IL-6-induced tyrosine 705 phosphorylation of Stat3."
21538419
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"Both autocrine and paracrine IL-6 can lead to constitutive phosphorylation of STAT3 at Tyr705 and Ser727 residues; IL-6 from paracrine sources (such as cancer-associated myeloid cells or fibroblasts) could induce autocrine IL-6 production and STAT3 phosphorylation in tumor cells (9)."
33313091
sparser
"We found that the effect of nm23-H1 depletion on IL-6-induced STAT3 Tyr705 phosphorylation was reversed by ectopic expression of shRNA-resistant nm23-H1 protein."
23583378
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"SHP2 increases robustness and information transfer of early IL-6-induced STAT3-Y705 phosphorylation and ensures independence of basal STAT3 phosphorylation from varying STAT3 expression."
| PMC
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"Kaempferol targeted IL-6-induced phosphorylation of STAT3 at Tyr 705 and p65 subunit of NF-κB at Ser 536 for the attenuation of COX-2 expression."
28955792
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"As expected, IL6 treatment led to phosphorylation of STAT3 on Tyr705."
24687132
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"IL-6 alone, IL-6 plus sIL-6R and LIF increased the phosphorylation of STAT3, most strongly at tyrosine 705 (tyr705) residue and to a milder degree at ser727 residue."
19267906
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"IL-6 is known to stimulate STAT3 phosphorylation on Tyr705 in many cancer cells."
29606890
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"Figure xref B shows that IL-6 stimulates phosphorylation of Tyr705 of STAT3 and expression of survivin in serum-starved A549 cells."
24661007
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"The IL-6 induction of STAT3 (Y705) phosphorylation was suppressed by 103% (p =.0003) with C188-9 treatment and was 50% lower (p =.01) than that of control myotubes (XREF_FIG)."
30918582
reach
"Indeed, IL-6 treatment induced Y705 phosphorylation of STAT3 in a time dependent manner concomitantly inducing FTO protein expression with a maximal effect at 6 hours of treatment, suggesting that FTO could be a target gene of STAT3 in hepatocytes."
24410832
sparser
"Sanguinarine inhibits constitutive as well as IL6-induced phosphorylation of Stat3 at both Tyr705 and Ser727 in prostate cancer cells."
21538419
sparser
"IL-6 induces STAT3 phosphorylation at Tyr-705 and Ser-727 through IL-6 receptors and JAK to activate STAT3 signalling in HCC cells."
26061710
sparser
"As expected, IL6 induced rapid phosphorylation of STAT3 Tyr705 within the first 30 minutes of treatment."
33618332
sparser
"We found that phosphorylation of STAT3 Tyr705 is induced by both IL-6 alone and in combination with sIL-6R (Fig.  xref , left) in a dose-dependent manner (Additional file xref : Figure S3)."
30185178
sparser
"By contrast, we also observed that both IL-6 and LPS induced STAT3 phosphorylation at tyrosine 705 and enhanced acetylation at lysine 685 ( xref )."
27866206
sparser
"We found that EB inhibited the IL-6-induced STAT3 Tyr705 phosphorylation in a dose and time-dependent fashion ( xref )."
26010889
sparser
"Consistently, knockdown of TRIM27 markedly inhibited IL-6-induced phosphorylation of STAT3 at Y705 (Fig.  xref )."
30143645
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"In addition, intracisternal injection of IL-6 by itself significantly increased phosphorylation of STAT3 at Tyr705 and Ser727."
16413512
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"Phosphorylation of the STAT3 Y705 residue can be induced by cytokines (IL-6, IFN-alpha), growth factors (EGFR, EGFRvIII, HER2 and PDGFR) and non receptor tyrosine kinases (Src and all the JAK family proteins) [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
24743777
reach
"However, IL-6 receptor activation induces the phosphorylation of both the Y705 and S727 residues of STAT3, and S727 phosphorylation is required to achieve maximal STAT3 transcriptional activity."
29082496
rlimsp
"STAT3 is the central mediator of IL-6-induced gene expression which is phosphorylated at Tyr705 by the receptor associated Janus kinases, an essential prerequisite for dimerization and nuclear translocation (1,3)."
18611949
reach
"This finding was confirmed in our study, in which the I/R increased phosphorylation of Akt (Ser473) and STAT3 (Tyr705) was further enhanced by IL-6."
33428604
sparser
"Localization of STAT3 to mitochondria increased after inducing STAT3 phosphorylation on tyrosine 705 by IL-6 (10 ng/ml)."
29702530
reach
"CPT inhibits interleukin 6 (IL6)-induced phosphorylation of STAT3 Tyr705 in gastric cancer cells."
28222632
sparser
"In our study, we showed that treatment with LPS or IL-6 alone markedly increased the phosphorylation of STAT3 at Tyr 705 and that CCM111 robustly decreased the phosphorylation of STAT3 at Tyr 705 in a dose- and time-dependent manner in macrophage cells or epithelial cells (Figs  xref and xref )."
28687744
reach
"Notably, in response to IL6, wild-type STAT3 was far more pronouncedly phosphorylated at tyrosine 705 (Y705) than STAT3 R414Q or STAT3 R417Q."
24721162
sparser
"On the other hand, BM-MSCs aid in EMT of LM tumor cells in the primary site through IL-6-induced phosphorylation of the Y705 residue on the STAT3 molecule."
33262462
sparser
"We demonstrate that IL-6 classic signaling causes transient phosphorylation of STAT3 Tyr705 , while trans-signaling also leads to phosphorylation of AKT Ser473 and ERK1/2 Thr202/Tyr204 ."
30185178
sparser
"HHT reversiblely inhibited IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression."
26166037
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"It has been shown that both IL-10 and IL-6 could induce STAT3 phosphorylation at Tyr705."
24513872
bel
"Addition of IL-6 is sufficient to increase levels of p-STAT3 in MDA-MB-453 and MCF-10A cell lines."
18939993
sparser
"AZD1480 inhibited IL-6−induced STAT3 phosphorylation at Y705 in the cells from IgAN patients (IgAN-PB and IgAN-tonsillar cells) and the control subjects (HC-PB and OSA-tonsillar cells) ( xref c and d, xref c and d)."
29270528
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"The IL-6 induction of tibialis anterior muscle gp130 expression, STAT3 (Y705) phosphorylation, and ERK1/2 phosphorylation were blocked by muscle gp130 loss (XREF_FIG)."
30918582
sparser
"Cavin-1 limits IL-6-stimulated Tyr705 STAT3 phosphorylation."
29330478
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"IL-6 stimulation leads to phosphorylation of STAT-3 (Tyr 705), and inhibition of STAT-3 by specific inhibitors or siRNA abrogates IL-6-induced invasion and integrin beta6 upregulation, indicating the participation of this classical signaling cascade in response to IL-6."
32855767
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"As expected, IL6 induced rapid phosphorylation of STAT3 Tyr705 within the first 30 minutes of treatment."
33618332
reach
"We demonstrate that IL-6 classic signaling causes transient phosphorylation of STAT3 Tyr705, while trans-signaling also leads to phosphorylation of AKT Ser473 and ERK1/2 Thr202 and Tyr204."
30185178
sparser
"Our data show that andrographolide reduced not only the levels of Stat3Tyr705 in DU145 cells that express constitutive IL-6 autocrine loop, but also the levels of IL-6-induced Stat3Tyr705 phosphorylation in LNCaP cells treated with exogenous IL-6."
21442031
sparser
"Phosphorylation of STAT3 Tyr705 (pSTAT3 Tyr705 ) was induced by OSM, LIF, CT-1, IL-11, and IL-6 ( xref )."
35163371
reach
"Surprisingly, the IL-6 stimulation in the RhoC knockdown cell lines phosphorylates STAT3 tyr 705; this strongly suggests that phosphorylation of STAT3 by RhoC can take place via IL-6."
24533098
reach
"In LNCaP cells where STAT3 is not constitutively active, the exogenous addition of IL-6 induced the phosphorylation of STAT3 at Tyr705 which had been reduced by JAK and STAT3 inhibitors."
24520293
reach
"As expected, we found that 50 ng/mL IL-6 activated STAT3 and induced STAT3 tyrosine phosphorylation on Tyr 705 in A549 and HCC827 cells."
24789104
bel
"IL-6 treatment resulted in increased p-STAT3 as well as Twist at protein and mRNA levels, and the induction was inhibited in the presence of JSI-124 (Fig. 2,Dand E)."
18353781
reach
"Phosphorylation of transcription factor STAT3 at Ser727 is associated with MAPK8 and MAPK1/3, whereas STAT3 phosphorylation at Tyr705 is mainly mediated by IL-6 and Janus kinases (JAK)."
29636527
sparser
"However, the depletion or deletion of AnxA2 had no effect on IL6-induced Tyr-705 phosphorylation of STAT3 (Supplementary Fig.  xref )."
| PMC
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"To determine whether AG490 and S3I-201 inhibit p-STAT3 (STAT3 activation) human LNCaP cells which do not constitutively express activated STAT3, IL-6 was exogenously added to induce the phosphorylation of STAT3 at Tyr705."
24520293
sparser
"While IL-6 did induce Y705 phosphorylation of STAT3 ( xref ), it did not strongly induce STAT1 phosphorylation ( xref ), or induce ISG expression, as measured by immunoblot."
34537236
sparser
"In parallel, stimulation of cells with IL-6 induced STAT3 Y705 phosphorylation after 30 minutes at the earliest time point and resumed after 48 hours ( Supplemental Figure S3 E)."
23438478
sparser
"IL-6 strongly induced STAT3 phosphorylation at Y705 but not S727 and was inhibited by WFA after only 2 hours of incubation ( xref ); however, total STAT3 levels were reduced after exposure of cells to WFA for more than 4 hours, suggesting that WFA also downregulates STAT3 protein if cells are exposed to the drug for longer time periods."
25452693
sparser
"We further identified a novel natural product inhibitor of STAT3, termed XYA-2, which interacts specifically with the SH2 domain of STAT3 (K d = 3.29μM) and inhibits IL-6-induced STAT3 phosphorylation at Tyr705 and nuclear translocation."
36804016
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"IL-6 also increased the phosphorylation of STAT3 (Tyr 705), a known event in the activation of the JAK and STAT signaling cascade (XREF_FIG C)."
19502419
sparser
"Andrographolide was able to block IL-6-stimulated Stat3Tyr705 phosphorylation, Erk phosphorylation, and Akt phosphorylation ( xref )."
21442031
reach
"In these cells IL-6 was found to induce phosphorylation of STAT3 on Tyr 705 and this was effectively inhibited by both trans-resveratrol and flavone, despite the lack of SOCS3 expression (XREF_FIG d)."
23782265
sparser
"In both naïve and antigen-stimulated (“primed”) CD4+ T cells, loss of MeCP2 did not alter the abundance or activity of STAT3 protein; however, it did dampen the IL-6–dependent phosphorylation of Tyr 705 of STAT3, the hallmark of STAT3 activation ( xref )."
24619648
reach
"When the STAT3 Ser727Asp mutant was overexpressed, IL-6 stimulation was still required to induce STAT3 Tyr705 phosphorylation and dimerization, while the IL-6-induced transactivation was not significa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11322950
sparser
"As a result, 3-DSC exhibited inhibitory effects on IL6-induced STAT3 phosphorylation at the Tyr705 residue at lower concentrations (0.1 and 0.3 μM), but STAT3 phosphorylation was unchanged at a higher concentration of the compound ( xref )."
27795451
reach
"In this study, phosphorylation of STAT3 at Y705 induced by IL-6 was weakly inhibited by AG490, a Jak2 kinase inhibitor, but not by cirsiliol at 90muM in the serum starved condition (XREF_FIG)."
33392396
sparser
"It has been shown that both IL-10 and IL-6 could induce STAT3 phosphorylation at Tyr705 ( xref )."
24513872
sparser
"CG-06 inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU-145 cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in DU-145 and LNCaP cell lines."
29807795
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"SC144 inhibited cell proliferation and viability and suppressed IL-6- and OSM-stimulated STAT3 Y705 phosphorylation in PDAC cells."
36495330
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"We observed that IL-6 at the concentrations from 10 to 100 ng/ml obviously enhanced pSTAT3(Y705) phosphorylation in both A2058 and A375 cell lines ( Figure S10 )."
35096622
reach
"Besides, it is well documented that IL-6 phosphorylates transcription factor Stat3 at Tyr705 residue and has a role in inflammation [XREF_BIBR - XREF_BIBR]."
24078775
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"Immunoblotting assays showed that sunitinib greatly inhibited the phosphorylation of STAT3 (Tyr705) induced by IL-6 in primary cultures from medulloblastoma (XREF_FIG)."
20053726
sparser
"Furthermore, HMC was also able to suppress the IL-6 induced phosphorylation of STAT-3 at serine 727 and tyrosine 705 residues in K-562 cells ( Fig. 6 D)."
26291658
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"As shown in XREF_FIG, after serum starvation, phosphorylation of Y705 in STAT3 was induced by IL-6 stimulation."
33392396
sparser
"Whereas IL-6 induced STAT3-Tyr705 phosphorylation within a few minutes, the stimulation of the BCR with anti-immunoglobulin M (IgM) antibodies required a few hours, since it involves the transcriptional activity of NF-κB. Remarkably, prolonged incubation with anti-IgM antibodies induces transcription and secretion of IL-6, further promoting the phosphorylation of STAT3 on tyrosine residues."
31817171
reach
"As expected, phosphorylation of STAT3 at both Ser727 and Tyr705 was induced by IL6 treatment."
24687132
reach
"By contrast, we also observed that both IL-6 and LPS induced STAT3 phosphorylation at tyrosine 705 and enhanced acetylation at lysine 685 (XREF_FIG)."
27866206
sparser
"TRIM27 deficiency also markedly inhibited IL-6-induced phosphorylation of STAT3 Y705 but not JAK1 Y1022/1023 (Fig.  xref )."
30143645
reach
"IL-6 increased Tyr705 phosphorylation of signal transducer and activator of transcription 3 (STAT3)."
19741197
sparser
"Fig. 1 shows that treatment of human MM cells (U266, H929, and IM-9 cells) with SNAC (200 μM) at 2 h before IL-6 treatment (20 ng/ml/0.5 h) significantly decreased the IL-6 induced STAT3 phosphorylat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28232202
sparser
"Therefore, both K685 acetylation and Y705 phosphorylation of STAT3 induced by IL-6 contribute to its activation in the regulation of Fra-1 gene expression."
25750173
sparser
"The IL-6-induced STAT3 phosphorylation at Y705 in IgAN-PB cells started to weaken after 1 hour, but was detected even after 48 hours ( xref a and b)."
29270528
sparser
"LLL12, prevents IL-6-induced STAT3 phosphorylation at Y705, and demonstrates efficacy in vivo in a TNBC MFP mouse model with a concomitant reduction in tumor volume and pSTAT3 expression (163)."
35371975
sparser
"In the present study, our data show that DHA and EPA suppress the IL6-induced Tyr705 phosphorylation of STAT3, which in turn inhibit the transcription activation of CPR gene."
25881314
sparser
"Studies have shown that IL-6 induces STAT3 phosphorylation on both Tyr705 and Ser727 [ xref , xref ]."
27074565
sparser
"Furthermore, consistent with our previous finding, IRAK-1 deletion did not affect STAT3 Tyr705 phosphorylation induced by IL-6 ( xref )."
19380824
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"Therefore, both K685 acetylation and Y705 phosphorylation of STAT3 induced by IL-6 contribute to its activation in the regulation of Fra-1 gene expression."
25750173
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"Phosphorylation of STAT3 (Y705) induced by IL-6 was greatest in naive T cells."
26912317
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"Furthermore, consistent with our previous finding, IRAK-1 deletion did not affect STAT3 Tyr705 phosphorylation induced by IL-6 (XREF_FIG)."
19380824
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"Again, rrCNTF failed to induce STAT3 phosphorylation in rat microglia while IL-6 stimulated strong phosphorylation of STAT3 tyr705 (Fig XREF_FIG)."
19267906
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"In contrast, phosphorylation of Stat3 Tyr705 by IL-6 was not inhibited by Bim-1."
24496235
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"Endogenous IL-6 functions as a potent activator of STAT3 and could restore the phosphorylation of STAT3 Tyr705 in BRM silencing PC cells and regulate phenotypic changes in these cells."
28602977
bel
"treatment with an sIL-6Ralpha/IL-6 transsignaling complex produced a transient increase in the phosphorylation of STAT3 on Tyr705, which plateaued at 15 and 30 min. In comparison, overexpression of the A2AAR significantly reduced STAT phosphorylation at each time point (Fig. 1B)."
20185553
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"Interestingly, the inflammatory cytokine IL-6 could induce a robust physical STAT3-NFATc2 interaction that was further enhanced by addition of serum (XREF_FIG) and that required STAT3 Y705 phosphorylation (XREF_FIG)."
26823495
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"In DDIAS-knockdown cells, PTPRM knockdown recovered the decrease in IL-6–mediated STAT3 Y705 phosphorylation."
31900385
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"The WB results showed that IL-6 activated the phosphorylation of STAT3 (Y705) and increased the MMP9 mRNA expression in ImKC educated by ANGTPL1-Exo in 24h."
33413536
sparser
"Phosphorylation of STAT3 at Tyr705 induced by IL-6 is inhibited by sorafenib."
20371721
sparser
"A time-course of IL-6-promoted STAT3 Tyr 705 phosphorylation demonstrated that naringenin began to exert a significant inhibitory effect after approximately 3 h stimulation ( xref b)."
23782265
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"Localization of STAT3 to mitochondria increased after inducing STAT3 phosphorylation on tyrosine 705 by IL-6 (10 ng/ml)."
29702530
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"Besides, it is well documented that IL-6 phosphorylates transcription factor Stat3 at Tyr705 residue and has a role in inflammation [ xref – xref ]."
24078775
reach
"In eight of nine ERalpha positive breast cancer cell lines, recombinant IL-6 increased phosphorylation of tyrosine 705 of STAT3."
26893580
sparser
"Overexpression of PASD1 enhanced both basal and IL-6-induced STAT3 phosphorylation at Y705, whereas knockdown of PASD1 had opposite effects."
26892021
reach
"As a mediator of cellular inflammatory response, phosphorylation of the transcription factor STAT3 at Y705, which among others is induced by IL-6, was assessed [XREF_BIBR]."
25400510
reach
"In cell assays, IL-6 and sIL-6R stimulation time-dependently promoted the activation and phosphorylation at site Tyr705 of STAT3 in RA-FLS, with a peak at 40min."
33594167
reach
"As shown in Figure XREF_FIG A, B, activation of IL-6 classic signalling in podocytes by IL-6 significantly increases the phosphorylation of STAT3 on Tyr 705 residue and leads to podocyte damage."
28881473
reach
"Because in unstimulated MM-1 cells STAT3 is not activated, we incubated the cells with IL-6 that induces phosphorylation of STAT3 on tyrosine 705 residues."
27076684
sparser
"In line with above described data, Western Blot analysis showed that DCE and CS decreased, in a dose-dependent manner, IL-6-induced tyrosine 705 phosphorylation of cytosolic STAT3 without affecting the total amount of STAT3 protein ( xref )."
21625597
sparser
"Recombinant IL-6 (10 ng/mL) increased STAT3-Tyr705 phosphorylation in eight of the nine ERα-positive cell lines evaluated by Western blot analysis ( xref and xref )."
26893580
sparser
"As expected, IL-6 alone strongly phosphorylated STAT3 at Y705, but, surprisingly, did not phosphorylate S727."
29410184
reach
"DDIAS depletion attenuated IL-6–induced STAT3 phosphorylation at Y705 but not at S727 in non-small cell lung cancer (NSCLC) cells, such as NCI-H23 and NCI-H1703 (Fig. 1b)."
31900385
sparser
"Here we show that CPT significantly inhibited constitutive and IL-6-induced phosphorylation of STAT3 Tyr705 in human gastric cancer cells without altering the phosphorylation of STAT3 Ser727 (pSer727), JAK1, and JAK2."
28222632
reach
"Previous studies have indicated that the IL-6 / gp130 and JAK signaling pathway can phosphorylate STAT3 Tyr705 in various tumor cells, including HCC [XREF_BIBR, XREF_BIBR]."
24655440
sparser
"Incubation with orthovanadate markedly increased IL-6-stimulated STAT3 Tyr705 phosphorylation, yet this was still markedly inhibited by A769662, indicating that AMPK-mediated inhibition is at the level of JAK activity rather than reduced STAT3 phosphatase activity ( xref )."
27840174
sparser
"We next tested whether SHP2 affects robustness of late IL-6-induced STAT3-Y705 phosphorylation."
| PMC
reach
"IL-6 induces STAT3 phosphorylation at Tyr 705 and Ser 727 through IL-6 receptors and JAK to activate STAT3 signalling in HCC cells."
26061710