IndraLab

Statements

Spautin-1 activates USP10. 2 / 2
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"Briefly, spautin-1 targets two ubiquitin specific peptidases (USP10 and USP13), both of which mediate deubiquitination of Beclin1 and p53, thus leading to their proteasomal degradation [93]."
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"Because the reductions in the levels of USP10 and USP13 in H4-LC3-GFP cells treated with spautin-1 appeared later than the reductions in the levels of Vps34 complexes and autophagy (XREF_FIG), the reduced levels of USP10 and USP13 are unlikely to be the primary reason for the ability of spautin-1 to reduce the levels of PtdIns3P and inhibit autophagy."
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