IndraLab

Statements

Structure activates PAN2. 2 / 2
| 2
eidos
"Our biochemical , biophysical , and structural investigations suggest that poly ( A ) forms an intrinsic base-stacked , single-stranded helical conformation that is recognized by Pan2 , and that disruption of this structure inhibits both Pan2 and Caf1 ."
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eidos
"Together , our data show that the intrinsic single-stranded helix of poly ( A ) is exploited by Pan2 for specificity and recognition , and that disruption of this structure is sufficient to inhibit Pan2 ( Fig. 6A ) ."
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