IndraLab

Statements

USP4 is phosphorylated on S445. 5 / 5
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rlimsp
"USP4 has both nuclear importing and exporting signal motifs and can shuttle between nucleus and cytoplasm10. Subcellular localization is partially controlled by AKT-mediated phosphorylation of the serine residue at position 445, which promotes cytoplasmic retention2."
26833277
sparser
"To examine whether the phosphorylation of USP4 at Ser445 affects the interaction between USP4 and Rheb, we generated a USP4 dephospho-mimetic mutant (USP4-S445A) and a phospho-mimetic mutant (USP4-S445D)."
30514904
sparser
"Taken together, these findings indicate that EGF regulates Rheb deubiquitination by inducing USP4 phosphorylation at S445."
30514904
sparser
"The study that identified USP4 as a DUB for ALK5 also demonstrated that phosphorylation of USP4 on S445 triggers homomeric and heteromeric complex formation with USP11, USP15 and USP19, suggesting that these DUBs could act as a complex xref ."
25007997
sparser
"Results have shown that AKT-mediated phosphorylation of USP4 at the Ser445 residue is essential for it to form a complex with itself or with other protein partners, such as USP15 or TβRI ( xref )."
34177595