IndraLab

Statements

HDAC6 binds CYLD. 17 / 22
3 | 6 8
reach
"The interaction between CYLD and HDAC6 was retained in the presence of nocodazole (XREF_FIG), indicating that the interaction between CYLD and HDAC6 does not require intact MTs."
19893491
biogrid
No evidence text available
19893491
sparser
"The interaction between CYLD and HDAC6 was retained in the presence of nocodazole ( xref ), indicating that the interaction between CYLD and HDAC6 does not require intact MTs."
19893491
sparser
"Furthermore, GST pull-down assays using the N-terminal region of CYLD (GST–CYLD 1–212 ) and the purified form of His-tagged, full-length HDAC6 confirmed an interaction between CYLD and HDAC6 ( xref )."
19893491
reach
"CYLD binding to HDAC6 increases alpha-tubulin acetylation."
19893491
biogrid
No evidence text available
19893491
reach
"Finally, CYLD also interacts with HDAC6 in the midbody where it regulates the rate of cytokinesis in a deubiquitinase independent manner."
19893491
reach
"Furthermore, GST pull-down assays using the N-terminal region of CYLD (GST-CYLD 1-212) and the purified form of His tagged, full-length HDAC6 confirmed an interaction between CYLD and HDAC6 (XREF_FIG)."
19893491
reach
"CYLD interacts with p62 directly and CYLD can directly inactivate HDAC6, thereby controlling autophagy [XREF_BIBR]."
25342597
sparser
"CYLD binding to HDAC6 increases α -tubulin acetylation."
19893491
sparser
"To this end, we immunoprecipitated HDAC6 from Cyld +/+ and Cyld −/− keratinocytes and found that TPA treatment, which was found to induce the interaction of CYLD and HDAC6, did not affect the association of HDAC6 with α-tubulin ( xref )."
19893491
sparser
"Finally, CYLD also interacts with HDAC6 in the midbody where it regulates the rate of cytokinesis in a deubiquitinase-independent manner."
19893491
sparser
"This hypothesis is supported by our finding that CYLD is unable to bind HDAC6 in the absence of TPA treatment."
19893491
sparser
"As expected, only the CYLD 1–212 fragment, which mediates the association of CYLD with HDAC6 ( xref ), was able to inhibit HDAC6 activity and subsequent α-tubulin deacetylation ( xref )."
19893491
sparser
"Activation of CYLD increases the levels of acetylated α-tubulin by interaction of the N-terminal domain of CYLD with the catalytic site of HDAC6."
19893491
reach
"To this end, we immunoprecipitated HDAC6 from Cyld +/+ and Cyld -/- keratinocytes and found that TPA treatment, which was found to induce the interaction of CYLD and HDAC6, did not affect the association of HDAC6 with alpha-tubulin (XREF_FIG)."
19893491
biogrid
No evidence text available
20593489