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USP26 activates SMAD7 deubiquitination. 1 / 1
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eidos
"Examples include ubiquitin-specific protease 10 ( USP10 ) , which can act on SMAD4 to make it deubiquitinated and stable , further promoting TGF-beta signaling [ 138 ] , and USP26 , which promotes SMAD7 deubiquitination , thereby amplifying the inhibitory effect of SMAD7 and strengthening the inhibition of the TGF-beta signaling pathway [ 139 ] ."