IndraLab
Statements
reach
"Lys48-linked Ub chains are highly abundant in cells (Kirkpatrick et al., 2006), and their conjugation to other proteins targets them for proteasomal degradation (Chau et al., 1989), but the molecular basis for DUB recognition of Lys48-linked Ub chains remains unclear.Ub-based chemical probes have been widely used to profile DUB activities and to stabilize monoUb-bound DUB complexes for structure determination (Ekkebus et al., 2013, Hemelaar et al., 2004)."
reach
"Lys48-linked Ub chains are highly abundant in cells (Kirkpatrick et al., 2006) , and their conjugation to other proteins targets them for proteasomal degradation (Chau et al., 1989) , but the molecular basis for DUB recognition of Lys48-linked Ub chains remains unclear.Ub-based chemical probes have been widely used to profile DUB activities and to stabilize monoUb-bound DUB complexes for structure determination Hemelaar et al., 2004) ."
reach
"While the molecular basis for monoUb specificity for many human and viral DUBs was revealed in structures of monoUb-bound DUB complexes, the molecular basis of Ub chain linkage specificity is understood only for a handful of DUBs (Keusekotten et al., 2013, Mevissen et al., 2013, Sato et al., 2015)."