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PSMD7 inhibits accumulation activation p53. 1 / 1
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"Our results showed that p53 , Mdm2 , p21 and Puma protein levels increased after PSMD7 knockdown in p53 wild-type A549 cells but remained steady or slightly decreased in p53-null H1299 cells ( Figure 5A ) , suggesting that PSMD7 depletion leads to the accumulation and activation of p53 ."