IndraLab

Statements

PI3K binds KCNG1. 5 / 5
| 5
sparser
"K13 could similarly associate with PI3K and promote its degradation."
28688800
sparser
"Their model of artemisinin mode of action ( xref ) proposes that the interaction between wild-type K13 and PI3K targets the latter for proteosomal degradation."
27337450
sparser
"A prior report associated ART resistance with elevated PI3P levels, mediated by an interaction between K13 and PI3K. The rise in PI3P levels in mutant parasites was attributed to reduced binding of K13 to PI3K, resulting in attenuated ubiquitin-mediated degradation of the kinase [ xref ]."
32310999
sparser
"K13 and PI3K associate with the parasite ER and are potentially involved in quality control of exported and cytoplasmic proteins [ xref , xref ]."
32569299
sparser
"In ART-resistant parasites harboring mutations in the K13 propeller domains, K13 cannot bind and target PI3K for proteasome-mediated degradation."
28688800