IndraLab

Statements


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"Consistent with previously published studies, elevating synaptic activity is associated with an increase in phosphorylation of Kv4.2 at ERK sites."

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"Moreover, kainate-induced status epilepticus was associated with an increase in ERK phosphorylation and reduction in surface expression of Kv4.2 channels in CA1 ( xref ), and theta burst stimulation of CA1 pyramidal neurons induced long-lasting LTP and increased ERK phosphorylation of Kv4.2 that leads to a reduction in channel conductance, an increase in neuronal depolarization and a facilitation of complex spike bursting ( xref , xref , xref )."