IndraLab

Statements

USP22 activates XPC. 3 / 3
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"After treatment with irradiation , XPC foci were significantly increased in LN-USP22hi and C42-USP22hi cells as well as decreased in LN-shUSP22 and C42-shUSP22 compared to corresponding controls ( Figure 5G ) , suggesting that USP22 modulates XPC activity basally and in response to genotoxic insult ."
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"Moreover , as Rad23B partners with XPC to sense and initiate NER , Rad23B foci formation was also increased basally and after irradiation in LN-USP22hi and C42-USP22hi cells ( Supplemental Figure 5F ) , further suggesting USP22 upregulation augments XPC activity ."
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"USP22 induced deubiquitylation of XPC without an increase of the protein half-life ( Supplemental Figure 5A ) , suggesting the alternative hypothesis that USP22 may modulate XPC activity through de-polyubiquitylation , as XPC is known to be polyubiquitylated to promote efficient DNA repair [ 32,33,39 ] ."
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