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TG binds USP10. 9 / 9
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"Furthermore, hematoxylin and eosin and Picrosirius red staining of heart sections indicated that hearts from USP10‐TG mice developed less cardiomyocyte hypertrophy and fibrosis in the interstitial and perivascular spaces than their USP10‐NTG littermates (Figure  xref through xref )."
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"Moreover, compared with the USP10‐NTG controls, the USP10‐TG mice exhibited significantly decreased LVEDd, LVESd, and increased fractional shortening values and ejection fraction values (Figure  xref through xref )."
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"In parallel, the mRNA levels of Anp, Bnp, Myh7, collagen Iα, collagen III, and Ctgf were markedly decreased in the hearts of USP10‐TG mice compared with those in the hearts of the USP10‐NTG controls (Figure  xref )."
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"We evaluated cardiac parameters in USP10‐NTG and USP10‐TG mice that were subjected to AB surgery to further confirm the regulatory function of USP10 in CH."
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"Methods and Results Cardiac-specific USP10 knockout (USP10-CKO) mice and USP10-transgenic (USP10-TG) mice were used to examined the role of USP10 in CH following aortic banding."
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"To determine whether USP10 overexpression could reduce pressure overload‐induced CH, we also generated cardiac‐specific USP10 transgenic mice (USP10‐TG) (Figure  xref and xref )."
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"As expected, the ratio of HW to BW was decreased in USP10‐TG mice compared with USP10‐NTG group at 4 weeks after AB surgery (Figure  xref )."
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"Cardiac‐specific USP10 knockout (USP10‐CKO) mice and USP10‐transgenic (USP10‐TG) mice were used to examined the role of USP10 in CH following aortic banding."
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"First, we tested Sirt6 level in USP10‐CKO and USP10‐TG mice."
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