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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

HCN channels activates HCN1. 2 / 2

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"Specifically, studies of the expression pattern of HCN channels following developmental prolonged febrile seizures and also kainate induced seizures found persistent loss of HCN1 mRNA and protein expression, transient downregulation of HCN2 expression and increased formation of heteromeric HCN1 and HCN2 channels."

26931806

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"cAMP shifts the voltage-dependence of activation in HCN2 and HCN4 by +15 mV, while HCN1 and HCN3 are only weakly modulated by cAMP2181920.The activity of HCN channels have been recently shown to be regulated by membrane lipids."

26404789

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...