IndraLab

Statements


RAF1 phosphorylates MAP2K1 on S218. 24 / 24
10 1 1 5 1 | 1 5

No evidence text available

rlimsp
"Phosphopeptide analysis demonstrated that serine residues 218 and 222 of human MEK1 are the primary sites for phosphorylation by c-raf."

No evidence text available

No evidence text available

reach
"Raf-1 phosphorylates MEK1 on two serine residues, Ser 218 and Ser222 [XREF_BIBR] MEK1 phosphorylates tyrosine and threonine residues in the ERK activation loop."

No evidence text available

No evidence text available

No evidence text available

No evidence text available

rlimsp
"In this report, we demonstrate a novel single step assay for Raf-1 kinase activity based on phosphorylation of recombinant MEK-1, detected using an activation-specific MEK antibody that recognizes MEK only when specifically phosphorylated by Raf-1 on Ser 217 and Ser 221."

No evidence text available

"Among other effectors, active ras binds and activates the raf kinase, iniziating a kinase cascade involving serine phosporylation of mek1/2 (mapkk) and tyrosine and threonine phosphorylation of erk1/2 active raf phosphorylates mek phospholpeptide analysis demostrated that serine residues 218 and 222 of human mek1 are the primary sites for phosphorylation by c-raf."

No evidence text available

No evidence text available

rlimsp
"RAF1 is known to phosphorylate MEK1 at serines 218 and 222 and the extent of this double phosphorylation is a reliable indicator of RAF1 activity (Bondzi et al., 2000)."

No evidence text available

rlimsp
"Activation of MEK1 by MEKK-C is accompanied by phosphorylation of S218 and S222, which are also phosphorylated by the protein kinases c-Mos and Raf-1."

No evidence text available

No evidence text available

rlimsp
"An activator of MAP kinases, Mek1, phosphorylates MAP kinases at threonine and tyrosine residues and is itself phosphorylated at serine-218 and -222 by the protooncogene product Raf-1."

No evidence text available

No evidence text available

No evidence text available

No evidence text available