IndraLab

Statements

reach
"Reduction of BK channel activation is unlikely to mediate the increase in excitability observed in cortical neurons following the block of N and P/Q Ca 2+ channels that we observed, since BK channels depend upon combined strong depolarization as well as muM increases in [Ca 2+] i."
20810905
reach
"In Fmr1 KO mice, BK channel activity is reduced in dendrites of neocortical neurons, leading to exaggerated Ca influx accompanying backpropagating APs and reduced dendritic spike threshold ."
33828309
reach
"One study reported that NS1619, a BK channel activator, inhibited the migration of glioma cells independently of intracellular calcium [115]."
38474212
reach
"In addition, SLO-1 and SLO-2 BK channels localize close to UNC-2 and EGL-19 voltage gated calcium channels, suggesting that SLO channels may inhibit calcium channels through functional coupling and negative feedback."
26771544
reach
"This hypothesis has not yet been investigated; however, it has been demonstrated recently that BK Ca channel dysfunction, caused by deletion of the gene mSlo1 for the pore-forming subunit of the BK Ca[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16243266
reach
"This suggests that the increased fEPSP during BAPTA-AM treatment is likely due to the broadening of the presynaptic AP through decreased BK channel opening, which in turn causes a larger entry of Ca 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18547679
reach
"Block of BK channels could lead to increased calcium entry during spontaneous firing by slowing action potential repolarization leading to longer activation of calcium channels and, by decreasing the AHP, BK channel block could slow deactivation of the calcium channels."
19446607
reach
"BK channel activation reduces the occurrence of dendritic calcium spikes."
18762971
reach
"Depolarization induced BK channel activation attenuates voltage dependent Ca 2+ channel activity in arterial myocytes, limiting vasoconstriction."
28487419
reach
"BK channel activation reduces intracellular calcium concentration via smooth muscle cell membrane hyperpolarization and consecutive inhibition of l-type calcium channels XREF_BIBR."
24497961
reach
"These findings imply that the absence of the BK channel restricts extracellular Ca influx in macrophages, ultimately augmenting AIM2 inflammasome activation."
38391935
reach
"The N-terminus of the BK channel inhibits the Ca α2δ subunit, which oversees Ca trafficking to presynaptic afferent terminals in the DRG and increases neurotransmitter release suggesting that the BK channel acts as a “brake” on neuronal hyperexcitability (Hayashi et al., 2016)."
38584598
reach
"These observations suggest that a physiological function of SLO-1 is to inhibit muscle Ca 2+ transients."
22131396
reach
"Located in close proximity to presynaptic voltage-gated calcium channels, MaxiK channels are thought to narrow the presynaptic action potential upon activation and therefore decrease presynaptic Ca entry, resulting in reduced neurotransmitter release."
24697223
reach
"These results are consistent with the idea that the main function of SLO-1 in presynaptic terminals is to negatively regulate calcium channel function."
25907097
reach
"The BK channel modulates STOCs, inhibiting Ca channels, acting as an “emergency brake” and negative feedback for muscle contraction (Latorre et al., 2017)."
38584598
reach
"The functional implications of BK channel lateral migration within the plasma membrane upon differential distribution of cholesterol between detergent-sensitive and detergent-resistant domains in mouse cerebral arteries, however, remains to be established.Current electrophysiological data also show that the slo1 channel Y450F substitution reduces the BK channel unitary current amplitude (Figure 2F), likely a consequence of Y450 being located next to the second Regulator of Conductance for the potassium (RCK) domain of the adjacent α subunit, in proximity to the inner leaflet and the calcium-sensing site."
| PMC
reach
"Both SLO mediated disruption of calcium transients and contractility deficits were reversible in the present study."
25243426
reach
"It has been proposed that genetic deletion [54] or reduced expression [55] of the BK channel β1 subunit reduces Ca sensitivity, making it impossible to induce STOCs in response to Ca sparks."
39731196
reach
"18,19 Maxi-K channel opening stimulated by Ca 2+ in the presence of a pharmacological opener would act to limit further Ca 2+ entry, thus interrupting the potentially fatal neurotoxic cascade initiate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12067560
reach
"A recent report suggests that in M4 motor neurons, UNC-2 and UNC-36 function to activate SLO-1, which in turn antagonizes the EGL-19 calcium channel to inhibit synaptic transmission at the M4 neuromuscular junction [XREF_BIBR]."
26771544
reach
"The results suggest that decreased BK channel activity and depolarized membrane potential in the VSMCs partly contributed to the increased vessel tone and [Ca (2+)] (i) in the HS offspring, adding new information for understanding mechanisms in vascular malfunctions in fetal origins, and novel insights for early prevention and treatments against such vascular diseases."
23013887
reach
"Phosphorylation of the BK channel by cGMP kinase lowers its voltage and Ca 2+ activation threshold."
10454212
reach
"Maxi-K channel opening stimulated by Ca 2+ and the pharmacological opener would function to limit further Ca 2+ entry by hyperpolarizing neurons, thereby reducing voltage dependent calcium entry point[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11909708
reach
"Here, we show that voltage- and calcium activated SLO BK potassium channels mediate gap junction signaling to inhibit calcium pathways for asymmetric AWC differentiation."
26771544
reach
"By contrast, acute functional blockade of the MaxiK channels by treatment with IBTX caused a progressive increase in [Ca 2+] i over a time period of 75 minutes in rat and human CCSM cells, and increased both the amplitude and efficacy of intercellular calcium signaling in rat CCSM cells."
21269393
reach
"Indeed, a BK channel blocker, penitrem A, effectively augmented Ca 2+ influx in male KO adrenal gland chromaffin cells, corroborating the critical role of BK channel activity in decreasing Ca 2+ influx in these cells."
29339804
reach
"Indeed, a common view is that BK channel activation leads to membrane hyperpolarization and decreases Ca 2 + entry through voltage-dependent Ca 2 + channels to promote relaxation."
24463006
reach
"Our results indicate that silencing of the MaxiK channel activates compensatory mechanisms to maintain calcium homeostasis."
21269393
reach
"We also show for the first time that slo-2 BK channels are important for AWC asymmetry and act redundantly with slo-1 to inhibit calcium signaling."
26771544
reach
"By contrast, acute functional blockade of the MaxiK channels by treatment with IBTX caused a progressive increase in [Ca 2+] i over a time period of 75 minutes in rat and human CCSM cells, and increased both the amplitude and efficacy of intercellular calcium signaling in rat CCSM cells."
21269393
reach
"Our model reproduces these dependencies, and action potential firing is only evoked in the model if both KCNQ and KCNMA1 channels are inhibited due to a loss of interaction with PI(4,5)P and Ca , respectively."
33967808
reach
"Cys911 oxidation in the BK channel α subunit decreases Ca sensitivity and impairs channel function [325]."
36674858
reach
"Furthermore, recent studies on the modulation of Maxi K (Ca) channels in smooth muscle cells have shown that both estrogen and tamoxifen increase the channel open probability by interacting with the b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12079691
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR Neuronal specific BKbeta4 has the opposite effects of BKbeta1, decreasing the apparent Ca 2+ sensitivity of the BK channel."
19447431
reach
"SLO completely suppressed the stimulatory effect of ATP on the release of [3 H] AA in the absence of calcium (from 211 +/-24% to 106 +/-3% (n = 3))."
9989292
reach
"Similarly, in hippocampal neurones, Li et al. (102) reported that nuclear BK channel block induced nucleoplasmic calcium elevation without changing cytoplasmic calcium concentration (102)."
35757775