IndraLab

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KCNMA1 inhibits calcium(2+). 29 / 29
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"Our results indicate that silencing of the MaxiK channel activates compensatory mechanisms to maintain calcium homeostasis."
21269393
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"XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR Neuronal specific BKbeta4 has the opposite effects of BKbeta1, decreasing the apparent Ca 2+ sensitivity of the BK channel."
19447431
eidos
"In freshly isolated coronary arterial SMCs of ZDF rats at 8 months after the development of hyperglycemia , BK channels had a rightward-shifted Ca 2 + concentration-dependent curve , with increased EC 50 for Ca 2 + activation and decreased Ca 2 + cooperativity , compared to those of Lean control rats ( Lu et al ., 2008 ) ."
34744789
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"These results are consistent with the idea that the main function of SLO-1 in presynaptic terminals is to negatively regulate calcium channel function."
25907097
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"In addition, SLO-1 and SLO-2 BK channels localize close to UNC-2 and EGL-19 voltage gated calcium channels, suggesting that SLO channels may inhibit calcium channels through functional coupling and negative feedback."
26771544
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"In Fmr1 KO mice, BK channel activity is reduced in dendrites of neocortical neurons, leading to exaggerated Ca influx accompanying backpropagating APs and reduced dendritic spike threshold ."
33828309
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"Phosphorylation of the BK channel by cGMP kinase lowers its voltage and Ca 2+ activation threshold."
10454212
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"Depolarization induced BK channel activation attenuates voltage dependent Ca 2+ channel activity in arterial myocytes, limiting vasoconstriction."
28487419
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"BK channel activation reduces intracellular calcium concentration via smooth muscle cell membrane hyperpolarization and consecutive inhibition of l-type calcium channels XREF_BIBR."
24497961
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"Indeed, a BK channel blocker, penitrem A, effectively augmented Ca 2+ influx in male KO adrenal gland chromaffin cells, corroborating the critical role of BK channel activity in decreasing Ca 2+ influx in these cells."
29339804
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"Maxi-K channel opening stimulated by Ca 2+ and the pharmacological opener would function to limit further Ca 2+ entry by hyperpolarizing neurons, thereby reducing voltage dependent calcium entry point[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11909708
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"BK channel activation reduces the occurrence of dendritic calcium spikes."
18762971
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"The changes in electrophysiological properties of GCs were attenuated after bath application of paxilline suggesting possible involvement of large conductance Ca (2+) - activated K (+) channel (BK channel)."
24711838
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"Our model reproduces these dependencies, and action potential firing is only evoked in the model if both KCNQ and KCNMA1 channels are inhibited due to a loss of interaction with PI(4,5)P and Ca , respectively."
33967808
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"Located in close proximity to presynaptic voltage-gated calcium channels, MaxiK channels are thought to narrow the presynaptic action potential upon activation and therefore decrease presynaptic Ca entry, resulting in reduced neurotransmitter release."
24697223
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"Both SLO mediated disruption of calcium transients and contractility deficits were reversible in the present study."
25243426
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"18,19 Maxi-K channel opening stimulated by Ca 2+ in the presence of a pharmacological opener would act to limit further Ca 2+ entry, thus interrupting the potentially fatal neurotoxic cascade initiate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12067560
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"These observations suggest that a physiological function of SLO-1 is to inhibit muscle Ca 2+ transients."
22131396
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"Reduction of BK channel activation is unlikely to mediate the increase in excitability observed in cortical neurons following the block of N and P/Q Ca 2+ channels that we observed, since BK channels depend upon combined strong depolarization as well as muM increases in [Ca 2+] i."
20810905
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"Furthermore, recent studies on the modulation of Maxi K (Ca) channels in smooth muscle cells have shown that both estrogen and tamoxifen increase the channel open probability by interacting with the b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12079691
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"Silencing MaxiK activity in corporal smooth muscle cells initiates compensatory mechanisms to maintain calcium homeostasis."
21269393
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"By contrast, acute functional blockade of the MaxiK channels by treatment with IBTX caused a progressive increase in [Ca 2+] i over a time period of 75 minutes in rat and human CCSM cells, and increased both the amplitude and efficacy of intercellular calcium signaling in rat CCSM cells."
21269393
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"Block of BK channels could lead to increased calcium entry during spontaneous firing by slowing action potential repolarization leading to longer activation of calcium channels and, by decreasing the AHP, BK channel block could slow deactivation of the calcium channels."
19446607
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"SLO completely suppressed the stimulatory effect of ATP on the release of [3 H] AA in the absence of calcium (from 211 +/-24% to 106 +/-3% (n = 3))."
9989292
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"The results suggest that decreased BK channel activity and depolarized membrane potential in the VSMCs partly contributed to the increased vessel tone and [Ca (2+)] (i) in the HS offspring, adding new information for understanding mechanisms in vascular malfunctions in fetal origins, and novel insights for early prevention and treatments against such vascular diseases."
23013887
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"We also show for the first time that slo-2 BK channels are important for AWC asymmetry and act redundantly with slo-1 to inhibit calcium signaling."
26771544
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"A recent report suggests that in M4 motor neurons, UNC-2 and UNC-36 function to activate SLO-1, which in turn antagonizes the EGL-19 calcium channel to inhibit synaptic transmission at the M4 neuromuscular junction [XREF_BIBR]."
26771544
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"Here, we show that voltage- and calcium activated SLO BK potassium channels mediate gap junction signaling to inhibit calcium pathways for asymmetric AWC differentiation."
26771544
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"By contrast, acute functional blockade of the MaxiK channels by treatment with IBTX caused a progressive increase in [Ca 2+] i over a time period of 75 minutes in rat and human CCSM cells, and increased both the amplitude and efficacy of intercellular calcium signaling in rat CCSM cells."
21269393