IndraLab

Statements

SCN1A inhibits NAV1. 2 / 2
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"It is caused by loss-of-function mutations in the gene SCN1A encoding brain sodium channel Nav1.1, which specifically impair action potential firing by GABAergic inhibitory interneurons and disinhibit neural circuits in the brain."
27481715
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"XREF_BIBR, XREF_BIBR Notably, conditional Scn1a +/- mice that have reduced Nav1.1 protein only in GABAergic interneurons show an overall phenotype similar to global Scn1a +/- mice."
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