IndraLab

Statements

Proteasome inhibits COPS5. 3 / 3
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"In combination with our previous data indicating that both exogenous and endogenous JAB1 are degraded by the proteasome following overexpression of ectopic JAB1 protein, these results suggest that JAB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10721695
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"We hypothesized that JAB1 is normally degraded by the 26S proteasome, therefore proteins that interact with JAB1 (such as Id3 and p27 Kip) may be targeted to the proteasome through their association w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10721695
reach
"These three JAMM domain DUBs are : Rpn11 in yeast (POH1 in humans) XREF_BIBR - XREF_BIBR, a subunit of the proteasome that cleaves ubiquitin chains from substrate proteins that are being degraded by the proteasome; CSN5, a subunit of the COP9 signalosome XREF_BIBR which cleaves Nedd8 (Neural Precursor Cell Expressed, Developmentally Down-regulated 8, a ubiquitin like protein) conjugates; and AMSH (associated molecule with the SH3 domain of STAM) a deubiquitinating enzyme involved in endocytosis XREF_BIBR."
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