IndraLab

Statements

PSMD14 activates TNBC. 4 / 4
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"In summary, these data showed that PSMD14 silencing strongly inhibited TNBC progression via the Akt/mTOR pathway in vivo, which synergistically exerted antitumor effects with exogenous AA supplementation."
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"PSMD14 promotes TNBC progression via Akt/mTOR pathway and synthetic lethality with AA supplementation in xenograft models."
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"In this study, we found that FADS1 can act as a functional downstream target of PSMD14, and PSMD14 can promote the progression of TNBC through the FADS1/Akt/mTOR signaling pathway."
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"Herein, we found that PSMD14 promotes the progression of TNBC by regulating FADS1 through the m A modification pathway mediated by the HNRNPC and SF3B4 complex, which is achieved by deubiquitylation of SF3B4.HNRNPs, a family of multifunctional protein molecules, are the m A reader proteins that were identified to play a crucial role in the m A recognition process by selectively identifying m A-modified mRNA sites (33)."
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