IndraLab

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"Treatment with MPA also increases the transcription of ubiquitin carboxyl-terminal hydrolase CYLD (log2FC 0.12, padj = 0.04), which is known to suppress the NF-κB, p38MAPK and c-Jun N-terminal kinase (JNK) cascades."
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"Overexpressing CYLD led to significant decreases in LPS-induced TNF-α and IL-6, at both the transcription and translation levels, compared to an empty vector (EV) (Fig. 3C, D)."
40108019
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"This indicates the importance of CYLD and NRF2 in macrophage TXNIP-mediated immune regulation during liver IRI.Nrf2 is a transcription factor that regulates the cellular defence against oxidative stress or ER stress via activating antioxidant genes."
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"Our study supported the involvement of six candidate genes in susceptibility to psoriasis : SCL12A8, which belongs to the solute carrier gene family; FLG and TGM5, which are involved in epidermal differentiation; CARD15 and CYLD, which modulate the transcription factor NF-kB; and IL1RN, which encodes an IL receptor antagonist."
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"CYLD (the familial cylindromatosis tumor suppressor gene) enhances the activation of the transcription factor NFkapa-B [XREF_BIBR], RBBP6, (which binds to the retinoblastoma gene product pRB) [XREF_BIBR], and PNUTL2 (which is an apoptosis related protein in the TGF-beta signaling pathway) [XREF_BIBR]."
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"These researchers found that the familial cylindromatosis tumour suppressor gene (CYLD), previously of unknown function, could enhance the activation of the transcription factor NF-kappaB, leading to increased resistance to apoptosis."
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