IndraLab

Statements

reach
"CYLD (the familial cylindromatosis tumor suppressor gene) enhances the activation of the transcription factor NFkapa-B [XREF_BIBR], RBBP6, (which binds to the retinoblastoma gene product pRB) [XREF_BIBR], and PNUTL2 (which is an apoptosis related protein in the TGF-beta signaling pathway) [XREF_BIBR]."
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"Our study supported the involvement of six candidate genes in susceptibility to psoriasis : SCL12A8, which belongs to the solute carrier gene family; FLG and TGM5, which are involved in epidermal differentiation; CARD15 and CYLD, which modulate the transcription factor NF-kB; and IL1RN, which encodes an IL receptor antagonist."
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"These researchers found that the familial cylindromatosis tumour suppressor gene (CYLD), previously of unknown function, could enhance the activation of the transcription factor NF-kappaB, leading to increased resistance to apoptosis."
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