IndraLab

Statements

USP7 binds MDM2 and MDM4. 4 / 4
| 4
sparser
"Phosphorylation defective mutants of MdmX (single-, double-, or triple- phosphorylation mutants) have reduced binding ability with Mdm2 but have enhanced binding activity with USP7 in the DNA damage stressed cells ( xref ), suggesting that DNA damage-induced phosphorylation of MdmX may influence binding of MdmX to Mdm2 and USP7."
19808970
sparser
"ATM- and PPM1G-dependent dephosphorylation of serine 18 in the N-terminus of Hausp has been reported to drive the DNA damage dependent disruption of Hausp interaction with Mdm2 and MdmX ( xref )."
25756610
sparser
"Under non-stressed conditions, for example, the MDM2-MDMX complex also binds to the deubiquitinating protein HAUSP, which stabilizes both MDM2 and MDMX ( xref , xref )."
23002429
sparser
"USP7 directly interacts with MDM2 and MDMX, regardless of p53 status."
32300595