IndraLab

Statements

USP10 binds HDAC6. 22 / 22
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sparser
"To determine whether USP10 binds to HDAC6 directly or via other proteins, we generated and purified recombinant GST-USP10 and His-HDAC6 in E. coli ."
32382008
sparser
"Implications of the USP10-HDAC6 axis in lung cancer - A path to precision medicine."
34746935
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"Finally, as the current landscape for the treatment of advanced lung cancer has shifted towards anti-PD-l/PD-L1-based immunotherapy [ xref ], further investigations to connect the USP10-HDAC6 axis to immunotherapy are certainly warranted."
34746935
sparser
"Overall, our data suggest targeting the USP10-HDAC6 axis in NSCLC lacking wild-type p53 (Fig. xref )."
32382008
sparser
"USP10 domain mapping found a more restricted binding pattern, as besides the full-length, the very C-terminal region (amino acids 700–798) was the only one necessary for the interaction between USP10 and HDAC6 to occur (Fig. xref )."
32382008
reach
"In the null-p53 or mutant-p53 background, USP10 may largely bind to HDAC6."
32382008
reach
"USP10 interacts with HDAC6."
32382008
reach
"Next, we mapped which domain (s) of HDAC6 binds to USP10, and vice versa."
32382008
sparser
"Our investigations then revealed that HDAC6 interacts with USP10, and it is a substrate of USP10."
34746935
reach
"To determine whether USP10 binds to HDAC6 directly or via other proteins, we generated and purified recombinant GST-USP10 and His HDAC6 in E. coli."
32382008
sparser
"Overall, we will gain a better understanding of the USP10-HDAC6 axis by an integrated genomics and proteomics approach."
34746935
sparser
"Our preliminary data indicates that p53 strongly interrupts the USP10-HDAC6 co-precipitation (data not shown), suggesting that p53 competes with HDAC6 for binding to USP10."
32382008
reach
"USP10 domain mapping found a more restricted binding pattern, as besides the full-length, the very C-terminal region (amino acids 700-798) was the only one necessary for the interaction between USP10 and HDAC6 to occur."
32382008
reach
"XREF_FIG, bacterially purified GST-USP10 and His HDAC6 were able to interact with each other under cell-free conditions via a GST pull-down assay, suggesting a direct interaction between USP10 and HDAC6."
32382008
sparser
"As shown in Fig. xref , bacterially-purified GST-USP10 and His-HDAC6 were able to interact with each other under cell-free conditions via a GST pull-down assay, suggesting a direct interaction between USP10 and HDAC6."
32382008
sparser
"USP10 interacts with HDAC6."
32382008
sparser
"As aforementioned both HDAC6 and USP10 regulate MSH2, we then tested whether USP10 and HDAC6 interact."
34746935
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"The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53."
32382008
sparser
"The USP10-HDAC6 Axis in a mutp53 Background."
34746935
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"Therefore, these results indicate that a USP10-HDAC6 axis exists, and that this axis plays an essential role in deciding cisplatin sensitivity and oncogenic functions of USP10 in the absence of wild-type p53."
32382008
sparser
"These results indeed verify that endogenous USP10 and HDAC6 interact with each other in lung cancer cells."
32382008
sparser
"In the null-p53 or mutant-p53 background, USP10 may largely bind to HDAC6."
32382008