IndraLab

Statements

UCHL1 activates Death. 6 / 6
| 6
reach
"Moreover, and identical to podocyte death caused by UCH-L1 overexpression, the addition of zVAD-fmk did not prevent TNF induced cell death, demonstrating that TNF indeed elicits necroptosis in podocytes, and that UCH-L1 represents a downstream mediator of the necroptotic signaling cascade of TNF also in podocytes."
24090154
reach
"Pathogenetic NH2-truncated Tau was also discovered in AD models, and it can trigger redundant mitophagy by promoting the excessive mitochondrial translocation of Parkin and UCHL-1, which finally cause[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33454337
reach
"In fact, estrogen treatment increases UCHL1 levels in endometrial cells [ 66 ], and induces germ cell death and downregulation of cyclin A1 and/or B1 in spermatogenic cells [ 23 , 24 ]."
34688693
reach
"We and others have previously observed this effect of zVAD-fmk in necroptosis [XREF_BIBR, XREF_BIBR, XREF_BIBR], excluding that de novo expression and thus increased UCH-L1 activity causes death of podocytes by apoptosis but rather pointing to programmed necrosis and necroptosis as the responsible suicide program."
24090154
reach
"No pathological data are currently available.It is not clear why mutations in alpha-synuclein, parkin or UCH-L1 genes cause nigral dopaminergic cell death in familial PD."
15018843
reach
"Since UCH-L1 clearly contributes to the non apoptotic death of podocytes, interference with the necroptotic properties of HtrA2 and Omi and UCH-L1 may prove beneficial for the treatment of patients, e.g. in kidney failure."
24090154