IndraLab

Statements

Wnt binds CTNNB1 and LEF1. 12 / 12
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"After accumulation, activated β-catenin translocates into the nucleus and forms a complex with the transcriptional factor T-cell factor/ lymphoid enhancer-binding factor 1 (TCF/LEF1) to initiate transcription of Wnt target genes [ xref ]."
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"Β-Catenin can then interact with members of the lymphoid enhancer factor/T-cell factor (LEF/TCF) family of architectural transcription factors in the nucleus, inducing transcription of Wnt-responsive genes (for reviews see xref ; xref )."
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"In the canonical Wnt pathway, β-catenin that migrates to the nucleus interacts with two transcription factors, T-cell-transcription factor (TCF) and lymphoid-enhancer-binding factor 1 (LEF-1), to indu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, treatment with the Rac1 inhibitor NSC23766 resulted in a marked reduction in interactions between β-catenin and LEF-1 in the nuclei of Wnt-treated cells ( xref B)."
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"In response to Wnt signals, β-catenin is stabilized and interacts with the N-terminus of Lef-1 to activate transcription of Wnt-responsive genes ( xref – xref )."
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"In the absence of Wnt ligand binding, cytoplasmic β-catenin is degraded by the ubiquitin-proteosome pathway and prevented from entering the nucleus and associating with Lef1 to activate Wnt target genes [ xref , xref ]."
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"Upon translocation to the nucleus, β-catenin forms a complex with transcription factors T-cell specific transcription factor (TCF) and Lymphoid enhancer binding factor (LEF) to drive transcription of key Wnt target genes including Axin2 and Nkd1 ."
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"In the presence of Wnt signaling, the accumulated β-catenin in cytoplasm and nucleus interacts with LEF1."
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"Nuclear RAC1 in complex with β-catenin facilitates RAC1-dependent phosphorylation of β-catenin on serines 161 and 605, resulting in the formation of nuclear β-catenin-LEF-1, which is necessary for the transactivation of Wnt-dependent genes [ xref ]."
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"In the canonical Wnt signaling pathway, the β-catenin in the nucleus forms a complex with LEF1 to activate transcription of the target gene [ xref ]."
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"In turn, the released EpICD associates with components of the Wnt pathway, β-catenin and LEF-1, and regulates gene transcription, inducing proliferation and tumorigenesis in mice."
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"Therefore, we want to know whether CHIP influences the interaction between LEF1 and β-catenin which then promotes Wnt signaling cascade."
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