IndraLab

Statements

BRAF activates MAPK1. 6 / 12
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"The mutations in the BRAF gene increase the kinase activity and, in turn, the constitutive stimulation of MAPK2 and MAPK3."
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"Overexpression of Rap1 and B-Raf activated MAPK extracellular dependent kinase (ERK) ERK-2 and ERK-dependent transcription factor Elk-1 in neuroendocrine cell lines Bon and INS-1."
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"In this situation, markedly diminished levels of BRAF and CRAF accompanied using shRNAs, reducing ERK1 and or ERK2 levels."
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"In the neuroendocrine cell lines, BON (lymph node metastasis of a pancreatic NEN) and INS-1 (a rat insulinoma cell line), over expression of Rap1 and B-Raf activated MAPK ERK-2 and ERK-dependent transcription factor Elk-1 has been noted xref ."
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"Pak2 and Pak4 further activate two Raf kinases, B-Raf and C-Raf, leading to ERK1 and ERK2 (ERK1/2) activation, which all seem to be necessary for EC lumen formation."
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"It was anticipated that expression of the truncated and constitutively activated form of BRAF would activate the ERK1 and ERK2 mitogen activated kinases (ERK1/2) so near-adjacent tissue sections to those stained for BRAF were also stained with an antibody against the phosphorylated and activated form of ERK1/2."
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