IndraLab
Statements
sparser
"Highlights d Protease-resistant diUb probes bind to DUB S1-S2 sites and react at the proximal end d First kinetic assay showing proximal end cleavage by DUBs using diUb-based substrates d OTUD3 binds K11-linked diUb and OTUD2 binds K11-and K33-linked diUb in S1-S2 pockets d Kinetics suggest different mechanisms for polyUb cleavage by OTUD2 and OTUD3 SUMMARY Ubiquitin chains are important post-translational modifications that control a large number of cellular processes."