IndraLab

Statements

USP4 binds NBN. 12 / 13
| 8 4
reach
"In cells, NBS1 and USP4 can form a complex, and the interaction between USP4 and NBS1 was upregulated by IR."
26387952
reach
"These results indicated that MRN complex binds USP4 and recruits USP4 to the DNA damage sites upon DNA damage."
26387952
sparser
"To further confirm that NBS1-USP4 interaction is indeed involved in NBS1-mediated USP4 recruitment, we stably transfected DR-GFP cells with NBS1 shRNA and reconstituted these cells with shRNA-resistan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26387952
sparser
"The results that CtIP interacts with MRN complex and works together in DNA end resection prompt us to think whether USP4 could bind NBS1, which is indeed the case ( Figure 2 A)."
26387952
sparser
"The above results indicated that USP4-NBS1 interaction is indeed involved in USP4 recruitment."
26387952
reach
"As shown in Figure 1 G, knockdown of CtIP by two different shRNAs did not affect USP4 recruitment to the DNA damage sites.The results that CtIP interacts with MRN complex and works together in DNA end[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26387952
reach
"Mechanistically, USP4 interacts with CtIP and MRN via a specific, conserved region and the catalytic domain of USP4, respectively, and regulates CtIP recruitment to sites of DNA damage."
26387952
reach
"They both demonstrated that USP4 interacts with CtIP and MRN and regulates the recruitment of CtIP to DSBs."
27602047
reach
"USP4 interacts with CtIP and MRN via the C-terminal insert domain (residues 572-773) and intact catalytic domain of USP4, respectively."
26387952
reach
"In light of the above findings, we tested whether USP4 might physically interact with CtIP and/or MRN."
26455393
sparser
"In cells, NBS1 and USP4 can form a complex, and the interaction between USP4 and NBS1 was upregulated by IR ( Figure 2 B)."
26387952
reach
"USP4, for example, interacts directly with end resection factors CtIP and MRN [172], USP21 deubiquitinates and stabilizes BRCA2 to promote RAD51 binding and successful HR [173], and USP10 deubiquitinates and stabilizes p53 to promote its nuclear localization and apoptosis in response to DSBs [174]."
32708614