IndraLab

Statements

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"Using oocyte expression and two-electrode voltage clamp (TEVC), we found that GABA activates KCNQ3* (an expression-optimized KCNQ3-A315T mutant that ensures robust currents ) and KCNQ5, especially at subthreshold potentials."
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"GABA activates KCNQ3 and KCNQ5."
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"GABA activates KCNQ3 and KCNQ5."
29748663
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"Thus, decreased GABA activation of KCNQ3-containing channels could lead to inhibition or disinhibition of neuronal activity in the visual cortex."
37305551
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"Electrophysiological recordings of cloned channels in Xenopus oocytes and CHO cells and endogenous M-current in PC12 cells and mouse dorsal root ganglia (DRG) neurons showed that KCNQ3 and 5, but not KCNQ2 or 4, are " activated " by sub-micromolar to micromolar levels of GABA, making these channels more sensitive than many canonical GABA receptors."
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"We previously found that while GABA binds to the S5 tryptophan of both KCNQ2 (W236) and KCNQ3 (W265), GABA activates homomeric KCNQ3, but not homomeric KCNQ2 xref ."
32111967
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"However, ionic permeability series experiments demonstrated that the relative permeability of Na + and Cs + compared to that of K + is increased by GABA activation of KCNQ3 and KCNQ5 channels but not by binding to KCNQ2 or KCNQ4 channels (which does not result in activation)."
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"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
29748663
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"We previously found that while GABA binds to the S5 tryptophan of both KCNQ2 (W236) and KCNQ3 (W265), GABA activates homomeric KCNQ3, but not homomeric KCNQ2 8."
32111967
eidos
"The hydrophobic pocket of the RTG binding site also seems to be able to accommodate endogenous hydrophilic neurotransmitters like gamma-aminobutyric acid ( GABA ) , which directly activates Kv7.3 and Kv7.5 via W236 ."
32499709
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"However, ionic permeability series experiments demonstrated that the relative permeability of Na + and Cs + compared to that of K + is increased by GABA activation of KCNQ3 and KCNQ5 channels but not by binding to KCNQ2 or KCNQ4 channels (which does not result in activation)."
32655402
sparser
"Here the authors show that GABA directly activates KCNQ3, at the residue required for its anticonvulsant activity."
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