IndraLab

Statements

reach
"Using oocyte expression and two-electrode voltage clamp (TEVC), we found that GABA activates KCNQ3* (an expression-optimized KCNQ3-A315T mutant that ensures robust currents ) and KCNQ5, especially at subthreshold potentials."
29748663
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"Electrophysiological recordings of cloned channels in Xenopus oocytes and CHO cells and endogenous M-current in PC12 cells and mouse dorsal root ganglia (DRG) neurons showed that KCNQ3 and 5, but not KCNQ2 or 4, are " activated " by sub-micromolar to micromolar levels of GABA, making these channels more sensitive than many canonical GABA receptors."
32655402
sparser
"Here the authors show that GABA directly activates KCNQ3, at the residue required for its anticonvulsant activity."
29748663
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"GABA activates KCNQ3 and KCNQ5."
29748663
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"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
29748663
eidos
"Remarkably , Manville et al. have recently reported that the neurotransmitter gamma-aminobutyric acid ( GABA ) and various metabolites ( beta-hydroxybutyric acid and gamma-aminobeta-hydroxybutyric acid ) directly activate Kv7.3 and Kv7.5 but not Kv7.1 , 2 , and 4 ."
32676036
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"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
29748663
reach
"However, ionic permeability series experiments demonstrated that the relative permeability of Na + and Cs + compared to that of K + is increased by GABA activation of KCNQ3 and KCNQ5 channels but not by binding to KCNQ2 or KCNQ4 channels (which does not result in activation)."
32655402
sparser
"However, ionic permeability series experiments demonstrated that the relative permeability of Na + and Cs + compared to that of K + is increased by GABA activation of KCNQ3 and KCNQ5 channels but not by binding to KCNQ2 or KCNQ4 channels (which does not result in activation)."
32655402
sparser
"GABA activates KCNQ3 and KCNQ5."
29748663
eidos
"The hydrophobic pocket of the RTG binding site also seems to be able to accommodate endogenous hydrophilic neurotransmitters like gamma-aminobutyric acid ( GABA ) , which directly activates Kv7.3 and Kv7.5 via W236 ."
32499709
sparser
"We previously found that while GABA binds to the S5 tryptophan of both KCNQ2 (W236) and KCNQ3 (W265), GABA activates homomeric KCNQ3, but not homomeric KCNQ2 xref ."
32111967
reach
"Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265."
29748663
reach
"We previously found that while GABA binds to the S5 tryptophan of both KCNQ2 (W236) and KCNQ3 (W265), GABA activates homomeric KCNQ3, but not homomeric KCNQ2 8."
32111967