IndraLab

Statements

VCL-D841H activates SCN5A. 3 / 3
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"The aggravation of loss of function of SCN5A caused by VCL-D841H under acidosis supports that nocturnal sleep respiratory disorders with acidosis may play a key role in the pathogenesis of SUNDS."
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"All these results suggest that VCL-D841H may be an independent risk factor for Chinese SUNDS through the interaction between VCL and SCN5A by which VCL-D841H causes SCN5A either loss or gain of function in the setting of environmental and/or genetic factors."
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"The significant aggravation of loss of function of SCN5A caused by VCL-D841H under acidosis further supports the idea that nocturnal sleep respiratory disorders with acidosis may play a crucial role in triggering the deadly arrhythmia underlying SUNDS victims."
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