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USP4 binds CTNNB1. 14 / 14
2 | 3 9
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"We further investigated the physical interaction between beta-catenin and USP4 through co-immunoprecipitation."
26189775
biogrid
No evidence text available
26189775
biogrid
No evidence text available
26189775
sparser
"Taken these results together, it was concluded that β-catenin activity is primarily associated with the C-terminal catalytic domain of USP4."
26189775
sparser
"We observed that both USP4(140–572) and USP4(261–963) bind to β-catenin, thus the second UBL domain (483–571) seems to have a major role in interaction with β-catenin ( Figure 4 )."
26189775
sparser
"These results suggest the association of the C-terminus of USP4(261–963) with a subset of β-catenin in the nucleus as evidenced by the observed binding ( Figure 4 B)."
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sparser
"USP4 was detected in β-catenin IP materials ( xref ), and β-catenin was found in USP4 IP materials ( xref ), suggesting that USP4 and β-catenin directly bind to each other."
26883469
sparser
"We further investigated the physical interaction between β-catenin and USP4 through co-immunoprecipitation."
26189775
reach
"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."
32140262
sparser
"The interaction of endogenous β-catenin and USP4 was confirmed in 293T and HCT116 cells, a colon cancer cell line harboring stable β-catenin that has a mutation at S45 phosphorylation site ( Figure 1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, we examined the direct interaction between USP4 and beta-catenin in our metastatic model system."
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sparser
"To further investigate the association of USP4 and β-catenin in colon cancers, we examined 30 human colon specimens (cancer and normal)."
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"Immunohistochemical analysis of colon cancer tissues supported the idea that the expression of β-catenin and USP4 are closely associated with colorectal cancer."
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sparser
"Thus, we examined the direct interaction between USP4 and β-catenin in our metastatic model system."
26883469