IndraLab

Statements

CTNNB1 binds USP4. 17 / 17
5 | 3 9
sparser
"USP4 was detected in β-catenin IP materials ( xref ), and β-catenin was found in USP4 IP materials ( xref ), suggesting that USP4 and β-catenin directly bind to each other."
26883469
sparser
"We further investigated the physical interaction between β-catenin and USP4 through co-immunoprecipitation."
26189775
sparser
"Taken these results together, it was concluded that β-catenin activity is primarily associated with the C-terminal catalytic domain of USP4."
26189775
biogrid
No evidence text available
30323974
sparser
"These results suggest the association of the C-terminus of USP4(261–963) with a subset of β-catenin in the nucleus as evidenced by the observed binding ( Figure 4 B)."
26189775
reach
"We further investigated the physical interaction between beta-catenin and USP4 through co-immunoprecipitation."
26189775
sparser
"The interaction of endogenous β-catenin and USP4 was confirmed in 293T and HCT116 cells, a colon cancer cell line harboring stable β-catenin that has a mutation at S45 phosphorylation site ( Figure 1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26189775
sparser
"To further investigate the association of USP4 and β-catenin in colon cancers, we examined 30 human colon specimens (cancer and normal)."
26189775
biogrid
No evidence text available
37039823
biogrid
No evidence text available
37039823
sparser
"Immunohistochemical analysis of colon cancer tissues supported the idea that the expression of β-catenin and USP4 are closely associated with colorectal cancer."
26189775
sparser
"We observed that both USP4(140–572) and USP4(261–963) bind to β-catenin, thus the second UBL domain (483–571) seems to have a major role in interaction with β-catenin ( Figure 4 )."
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reach
"Thus, we examined the direct interaction between USP4 and beta-catenin in our metastatic model system."
26883469
biogrid
No evidence text available
26189775
biogrid
No evidence text available
26189775
sparser
"Thus, we examined the direct interaction between USP4 and β-catenin in our metastatic model system."
26883469
reach
"XREF_BIBR - XREF_BIBR In addition, the deubiquitinating enzymes USP34 and USP7, CYLD and USP9X and USP4 can bind to Axin, Dvl and beta-catenin, respectively, thereby promoting the nuclear localization of beta-catenin and the Wnt signaling pathway by inhibiting their ubiquitination."
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