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Spautin-1 inhibits USP10. 14 / 14
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"Indeed, a recent study showed that a small molecule, Spautin-1, promoted the degradation of Vps34 by inhibiting two ubiquitin specific proteases USP10 and USP13 that regulate the stability of the Vps34 complex [XREF_BIBR]."
22185891
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"58 Spautin-1 promotes the degradation of BECN1 by inhibiting 2 USPs (ubiquitin-specific peptidases), USP10 and USP13, which target BECN1."
27541856
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"A study by Liu et al. (Liu et al., 2011) has demonstrated that Spautin-1 is a potent small-molecule inhibitor of USP10 and USP13, and treatment with Spautin-1 inhibits the deubiquitinase activity of USP10 and USP13, resulting in an increasing ubiquitination and accelerating degradation of Beclin1 in Vps34 complexes, ultimately inhibiting autophagy."
30319415
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"Spautin-1 inhibits ubiquitin specific peptidases, USP10 and USP13, and promotes the degradation of Vps34-PI3 kinase complexes, key regulators of autophagy, leading to inhibition of autophagy."
26732534
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"Consistent with these findings, inhibition of USP10 by Spautin-1 resulted in accumulation of CCND3 with K48-linked polyubiquitination and degradation that synergized with Palbociclib, a CDK4/6 inhibitor, to induce MM cell apoptosis."
37055530
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"SBI blocks the kinase activity of ULK1, diminishing the phospho regulated capacity of beclin-1 to engage with its binding partners (Egan et al., 2015) and Spautin-1 inhibits the USP10 and USP13 hydrol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29526763
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"A previous study reported that Spautin-1 also inhibits USP10 activity XREF_BIBR."
28569838
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"Spautin-1 inhibits the catalytic activity of both USP10 and USP13 with an IC 50 of ~ 0.6-0.7 microM."
30126257
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"Molecular analysis revealed that Spautin-1 directly inhibits the activity of the deubiquitinating enzymes (DUBs) ubiquitin specific protease 10 (USP10) and USP13."
25545884
tas
No evidence text available
25364867
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"To further determine whether USP10 could be a druggable target in these patients, we evaluated the ex vivo antineoplastic effect of pharmacological inhibition of USP10 by Spautin-1 on primary monocytes from 16 patients with CML."
31044085
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"Spautin-1 inhibits autophagy by reducing the activity of USP10 and USP13, which promotes a major aspect of autophagy: degradation by Vps34 complexes."
35627217
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"Spautin-1 inhibits the activity of the deubiquitinating enzymes USP13 and USP10."
29186924
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"Spautin-1 inhibits the activity of two ubiquitin specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy [XREF_BIBR]."
28575052