IndraLab

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ATXN3 activates BECN1. 5 / 5
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"Beclin-1 stabilization is also promoted by USP19 and ataxin 3, which specifically removes K11- and K48-ubiquitin chain from Belcin-1, respectively [38, 39]."
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"Another recently described interactor of Beclin-1 is valosin-containing protein (VCP/p97), which stimulates both the formation of the PI3K complex as well as ataxin-3 mediated stabilization of Beclin-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The polyglutamine domain of the wild-type ataxin-3 was found to interact with the pro-autophagic protein Beclin 1, whereby the deubiquitinase activity of ataxin-3 prevented the proteasomal degradation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, the ratio of LC3-II and LC3-I and LC3 total levels (XREF_FIG, D) are enhanced in MJD fibroblasts overexpressing beclin-1, particularly in the presence of chloroquine, reaching similar levels as CTRL fibroblasts (XREF_FIG), which indicates that although the number of autophagosomes is decreased, the autophagic flux can be restored."
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"According with the literature, the polyQ stretch in wild-type ataxin-3 induces autophagy by protecting Beclin-1 from proteasome-mediated degradation (Ashkenazi et al., 2017)."
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