IndraLab

Statements

AGT decreases the amount of KCNH2. 5 / 5
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"Mechanistically, an increase in PML SUMOylation by ATO or Ang II dramatically enhanced the formation of PML and Pin1 complexes in PML-NBs, leading to the upregulation of TGF-beta1 protein, eventually inhibiting HERG expression through activation of protein kinase A."
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"ATO or Ang II inhibited HERG protein expression in cardiomyocytes."
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"Immunoblot analysis indicated that GA treatment partially abolished PML SUMOylation that was induced by ATO or Ang II, consequently reversing the decreased HERG protein expression caused by ATO and Ang II."
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"Cai et al. also showed that Ang II reduced the expression of mature HERG channel protein by accelerating channel proteasomal degradation through AT1 receptor by PKC activation in HEK-293 cells with stably expressed HERG channel proteins [XREF_BIBR]."
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"Western-blot analysis showed that Ang II significantly decreased the expression of mature hERG channel protein (155-kDa band) in a time- and dose dependent manner without affecting the level of immature hERG channel protein (135-kDa band)."
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