IndraLab

Statements

eidos
"A recent proposal is that MDA5 functions as a '' molecular ruler : '' whereas relatively short dsRNAs ( $ 100 nt ) can activate MDA5 when present in large quantites , longer dsRNAs ( 1-2 kb ) do so more efficiently as a result of the cooperative assembly of the helicase along dsRNA stems , the complex created by which forms filamentous oligomers that are important for signaling ( see below ) Feng et al ., 2012 ; Peisley et al ., 2012 ; Wu et al ., 2013a ) ."
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reach
"This dsRNA contains inosine and inhibits the activation of MDA5 and RIG-1, thus turning off the interferon response and apoptosis to prevent autoimmune reaction."
35447886
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"Immunofluorescence analysis using specific dsRNA antibodies showed a significant and time-dependent accumulation of dsRNA in the USP18 KO cells after IFN treatment, indicating that USP18-dependent ISGylation under these conditions could inhibit ADAR activity.In addition to ADAR, PKR, RIG-I and MDA5, we found other proteins involved in antigen presentation and resistance to immunotherapy, such as TAP1, GBP1, STAT1, IFIT1, PSMB10, PSMB9, GBP2, MAGE and PARP14, also regulated by USP18-dependent ISGylation."
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"PKR is an intracellular protein that binds dsRNA in a length-dependent fashion and induces apoptosis in the host cell to prevent viral propagation.12 TLR3 , MDA5 , and RIG-I also recognize dsRNA and play an active role in immune activation ."
32913891
eidos
"A recent proposal is that MDA5 functions as a `` molecular ruler : '' whereas relatively short dsRNAs ( ~ 100 nt ) can activate MDA5 when present in large quantites , longer dsRNAs ( 1-2 kb ) do so more efficiently as a result of the cooperative assembly of the helicase along dsRNA stems , the complex created by which forms filamentous oligomers that are important for signaling ( see below ) ( Berke and Modis , 2012 ; Berke et al ., 2012 ; Feng et al ., 2012 ; Peisley et al ., 2012 ; 2011 ; Wu et al ., 2013a ) ."
23706667
reach
"Taken together, the results indicated that certain sites in the 3’UTR are efficiently edited by a very limited amount of ADAR1 p150 in the mouse brain, which might affect the dsRNA structure required to prevent MDA5 activation."
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"Mechanistically, adenosine-to-inosine (A-to-I) base modification of endogenous dsRNA by ADAR1 prevents chronic overactivation of the dsRNA sensors MDA5 and PKR 3,7-10,13,14 ."
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