IndraLab

Statements

USP1 binds EZH2. 10 / 10
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"To further test the effect of USP1-EZH2 axis on the target protein expression, we constructed an EZH2 variant, EZH2–421R/641F, which is resistant to the proteasome-mediated protein degradation ( xref , xref )."
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"beta-catenin/TCF4 activated transcription of the deubiquitinase USP1, which then interacted with and deubiquitinated EZH2 directly."
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"We next detected the interaction between USP1 and EZH2."
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"We next detected the interaction between USP1 and EZH2."
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"Moreover, reciprocal co-immunoprecipitation experiments showed that endogenous USP1 and EZH2 interacted with each other in U87MG and GSC11 cells ( xref )."
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"Thus, these results strongly support that USP1 interacts with and deubiquitinates EZH2 directly."
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"USP1 and EZH2 interact with each other and overexpression of USP1 diminishes the ubiquitination of EZH2, which is further enhanced by the overexpression of USP1 binding partner, WDR48."
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"Herein, our study identifies USP1 as a novel deubiquitinase which stabilizes EZH2 during glioma tumorigenesis, and demonstrates that the USP1-EZH2 axis plays a critical role in the malignant transformation of glioma cells."
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"We found that β-catenin induced the expression of USP1, which then interacted and deubiquitinated EZH2 directly to suppress the ubiquitin-proteasomal degradation of EZH2."
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"USP1 interacts with and deubiquitinates EZH2 directly.."
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