IndraLab

Statements

PR-619 inhibits ZUP1. 5 / 5
| 5
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"Notably , inhibition of DUB activities by PR-619 in the cell lysate-based experiment is more pronounced than that in the cell-based experiment ."
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"As expected , PR-619 strongly inhibited the activities of almost all DUBs tested , and SJB3-019A inhibited most of USPs but not OTUs , and its inhibitory efficiency was different for individual USPs ( Figure 4B and Table S3 ) ."
| PMC
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"For example , one study used ABPs to demonstrate the selectivity of P22077 for USP7 in cells , in contrast to PR-619 , which inhibited a broad range of DUBs 239 ."
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"Treatment of HeLa cells with high concentrations of PR-619 ( 50 muM ) led to reduced intensity in many labeled DUB bands , indicating intracellular inhibition of DUB activity by PR-619 ( Figure 6 ) ."
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"The recent study on the DUB selectivity of literature inhibitors by MALDI-TOF MS agreed that PR-619 strongly inhibits all DUBs tested ( covering USP / UCH / MJD / OTU families ) at 5 muM ."
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