IndraLab

Statements

SPATA2 binds CYLD and USP. 4 / 4
| 4
sparser
"Importantly, the USP domain of CYLD binds to the PUB domain of SPATA2, and the PIM in SPATA2 associates with the PUB domain of HOIP ( xref ) [ xref , xref , xref , xref ]."
32403254
sparser
"Importantly, the USP domain of CYLD binds to the PUB domain of SPATA2, and the PUB-interacting motif (PIM) in SPATA2 associates with the PUB domain of HOIP ( xref , xref – xref )."
33329596
sparser
"The N Terminus of SPATA2 Interacts with the USP Domain of CYLD, whereas Its C Terminus Binds to the PUB Domain of HOIP."
27545878
sparser
"Together, these results show that SPATA2 contains two distinct domains that are responsible for mediating the interaction with CYLD and HOIP, respectively; while the N terminus of SPATA2 binds to the USP domain of CYLD, the interaction with HOIP is mediated via a highly conserved PIM located in the central portion of SPATA2, which is recognized by the PUB domain of HOIP."
27545878