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PSMD14 increases the amount of GRB2. 5 / 5
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"To summarize, our study reveals a previously unknown mechanism of the role of PSMD14 in HCC progression, wherein GRB2 expression is posttranslationally upregulated by PSMD14, resulting in tumor growth[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The knockdown of PSMD14 significantly decreased the GRB2 protein expression in HCC cells ( Fig. 4 C)."
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"However, depletion of PSMD14 could not have an effect on GRB2 mRNA expression levels ( Supplementary Fig. 2A ), indicating that PSMD14 modulated GRB2 expression through a post-transcriptional mechanis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these findings suggested that PSMD14 functions upstream of GRB2 to regulate HCC progression.Based on our experimental findings on HCC cell lines that PSMD14 could increase GRB2 express[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that PSMD14 increased the protein levels of GRB2; however, it did not influence the mRNA levels of GRB2."
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