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USP14 activates HIF1-α. 2 / 2
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"On the other hand, our results also indicate that USP14 may modulate HIF1-α action through K63-linked deubiquitination beyond protein degradation."

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"Having established that USP14 as a deubiquitinase enhances the transcriptional activity of HIF1-α, we thus turned to analyze the mechanism underlying the modulation function of USP14 on HIF1-α action."