IndraLab

Statements

MDM2 inhibits USP7. 4 / 4
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"As expected, MDM2, which is a known USP7 substrate, was decreased by RNAi-mediated knockdown of USP7 and this effect was also reversed by MG132."
33933455
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"As shown in XREF_FIG, both p53 and Mdm2 had decreased half-lives in hausp heterozygote MEF cells (lanes 5-8) compared with that in wild-type MEF cells (lanes 1-4)."
19946331
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"The results indicated that the mRNA level of MDM2, p21, PUMA, TP53INP1, TP53INP2, GDF15, and IGFBP3, is elevated upon knockdown of either ECT2 or USP7, albeit to variable extents, while the expression of TP53 is unchanged."
32929379
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"Interestingly, the Mdm2 level decreased after depletion of HAUSP (XREF_FIG, lane 6 versus lane 5), consistent with the previous finding that Mdm2 is a substrate of HAUSP, and Mdm2 is destabilized in hausp knockout cells."
21350561