IndraLab

Statements

TP53 binds UBE4B and MDM2. 7 / 7
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"In 2011, Wu et al. showed that UBE4B physically interacts with p53 and Hdm2 and negatively regulates p53 stability and function xref ."
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"Similarly, UBE4B having E3 and E4 ligase activities binds to p53 and MDM2 and leads to inhibition of p53 dependent apoptosis (Wu et al., xref )."
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"In addition, UBE4B physically interacted with Hdm2 and p53 in vivo , and UBE4B negatively regulates p53."
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"In addition, the E4 ligase UBE4B interacts physically with p53 and MDM2 to polyubiquitylate p53 (Wu et al., xref )."
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"The combined results proved that UBE4B interacts with both p53 and Hdm2."
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"Progression to the polyubiquitinated form of p53 in the nucleus is carried out by the U-box E4 ligase UBE4B that interacts with both MDM2 and p53 ( xref ; xref ; xref )."
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"UBE4B physically associates with p53 and MDM2,and then promotes p53 polyubiquitination, which results in p53 degradation, thus inhibiting p53-mediated transactivation and apoptosis. xref "
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