IndraLab

Statements

USP12 activates Chemokine. 3 / 3
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"Given the relevance of the USP12-mediated chemokine, such as CXCL8, CXCL1 and CCL2, in tumour development and progression, we examined the mechanism underlying the USP12-mediated regulation."
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"Of note, the altered production of the chemokines caused by USP12 downregulation in tumour cells may also regulate T cell infiltration and function."
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"This study demonstrated that AKT-mTOR hyperactivation resulted in USP12 downregulation, which in turn increased the production of protumourigenic chemokine in NSCLC, indicating that USP12 is a regulatory node in oncogenic mutation-driven TME development.The tumour suppressive function conveyed by USP12 is virtually related to the control of protumourigenic chemokine expression."
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