IndraLab

Statements

CYLD activates JNK. 7 / 7
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"2 The inhibition of CYLD function in keratinocytes enhances the activation of the JNK pathway."
21900959
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"In agreement with the reported negative regulation of JNK and c-Myc activation by CYLD [ xref ], WB analysis of these molecules showed increased Akt, JNK and c-Myc activation (measured as levels of P-Akt, P-JNK and P-c-Myc respectively) in the skin of transgenic mice lacking the DUB function ( xref )."
30631004
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"In agreement with the reported negative regulation of JNK and c-Myc activation by CYLD [XREF_BIBR], WB analysis of these molecules showed increased Akt, JNK and c-Myc activation (measured as levels of P-Akt, P-JNK and P-c-Myc respectively) in the skin of transgenic mice lacking the DUB function (XREF_FIG)."
30631004
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"Moreover, we found that CYLD m not only increased JNK activity but also increased K63 ubiqutination on both c-Jun and c-Fos, and ultimately potentiated AP1 transcriptional activity."
21478324
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"Curiously, in CD3+ CD28 stimulated Jurkat T cells, MALT1 cleaves CYLD increasing activation of JNK, but not NF-kappaB [XREF_BIBR]."
23474202
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"In support of this view, MALT1 proteolysis of the inhibitory deubiquitinases A20 and CYLD potentiates NF-kappaB and JNK, respectively [XREF_BIBR, XREF_BIBR], while cleavage of the RNase Regnase-1 prolongs mRNA stability of T cell effector genes [XREF_BIBR]."
25965667
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"CYLD Inhibits Tumorigenesis and Metastasis by Blocking JNK and AP1 Signaling at Multiple Levels."
21478324