IndraLab

Statements

CHEK2 phosphorylates TP53 on serine. 22 / 22
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"In addition, the ATM dependent chk2 protein phosphorylates p53 at serine 20."
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"Note that ATM also activates check point kinase 2 (Chk2), which then phosphorylates p53 on Serine 20 [27]."
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"Recent data [45-47] show that activated Chk2 and Chk1 phosphorylate p53 on serine 20, an event which leads to decreased protein turnover and thus accumulation of p53."
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"ATM is also known to phosphorylate Chk2, which subsequently phosphorylates p53 on serine 20 [XREF_BIBR]."
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"On the other hand, activation of ATM leads to direct phosphorylation of p53 on serine 15 and 37, as well as phosphorylation and activation of another checkpoint kinase (CHK2), which also phosphorylates p53 on serine 20."
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"PML neutralizes the inhibitory effects of Mdm2 by prolonging the stress induced phosphorylation of p53 on serine 20, a site of the checkpoint kinase 2 (Chk2)."
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"For example, after DNA damage p53 is multiply phosphorylated, with the phosphorylation of Serine 15 by ATM enhancing its transcriptional activity and promoting other phosphorylations, while the ATM ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_BIBR In response to ionizing radiation, the kinase activity of ATM is enhanced, leading to phosphorylation of p53 on serine 15 and activation of the checkpoint kinase Chk2, which, in turn, phosphorylates p53 on serine 20."
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"The serine 20 of p53 is phosphorylated by Chk2, and thereby interrupts the binding of p53 to Mdm2 and interrupts p53 ubiquitination, resulting in greater stability of p53 [XREF_BIBR]."
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"P53 is targeted for deg- radation by binding with the MDM2 protein, which transfers a small polypeptide molecule called ubiquitin onto p53.37-4In response to IR, ATM phosphorylates MDM2 on serine 395 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This group has demonstrated that Chk2 is able to phosphorylate p53 on serine 20, and that this phosphorylation event triggers dissociation of preformed complexes between p53 and MDM2 under in vitro co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"ATM-activated Chk2 kinase also phosphorylates p53 at the threonine-18 and serine-20 residues [63,64]."
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"ATM phosphorylates p53 at serine 15 XREF_BIBR, XREF_BIBR, whereas Chk2 phosphorylates p53 at serine 20 in response to activation by ATM XREF_BIBR, XREF_BIBR."
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"After exposure to IR, phosphorylation of the serine residues 15 and 20 on p53 by checkpoint kinase 2 (CHK2) reduces its binding to MDM2, which in its bound state targets p53 for degradation by the proteasome pathway (Figure xref )."
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"Moreover, PML is capable of enhancing p53 stability through sequestering MDM2 [XREF_BIBR] or inhibiting MDM2 mediated p53 degradation via prolonging the phosphorylation of p53 on serine 20 by Chk2 [XREF_BIBR]."
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"XREF_BIBR, XREF_BIBR Chk2 directly phosphorylates p53 on serine 20, which is known to interfere with Mdm2 binding, thus providing a mechanism for the increased stability of p53 in response to DNA damage."
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"Checkpoint kinase 2 (CHK2) a key downstream target of ATM (Matsuoka et al., 1998) and mediator of ATM signalling also phosphorylates p53, on serine 20 (Chehab et al., 1999, 2000)."
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"N-terminal phosphorylation of p53 at serine residues S15 and S20 by ATM, ATR, CHK1 and CHK2, and other kinases stabilizes and activates p53 [XREF_BIBR, XREF_BIBR]."
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"ATM and its effector protein Chk2 play a role in the phosphorylation of p53 (serine 15) and activation of p53 in response to oxidative stress [XREF_BIBR] and also in cell cycle arrest in response to oxidative stress [XREF_BIBR, XREF_BIBR]."
19906512
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"Chk2 phosphorylates serine 216 of Cdc25C, serine 988 of Brca 1, and serine 20 of p53 in response to double-strand breaks."
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"Activated CHEK2 phosphorylates P53 at serine 20 50 CDC25A at serine 123 51 and CDC25C at serine 216 thus, contributing to the G1/S, S, and G2/M checkpoints respectively 52."
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"Chk2 phosphorylates p53 at serine 20 and interferes with the p53-Mdm2 interaction serving to stabilize p53 (see above)."
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