IndraLab

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ASXL3 activates BAP1. 3 / 3
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"Our in vitro analysis indicates that also ASXL3 can bind and activate BAP1, which is not surprising in the light of the high sequence similarity between the DEUBAD domains in the ASXL family."
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"The DEUBAD domains of ASXL1, ASXL2 and ASXL3 can activate BAP1 by increasing its affinity for ubiquitin."
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"In this paper we describe that similar to the homologous UCH-L5 and RPN13 DEU complex, the DEUBAD domains of ASXL1, ASXL2 and ASXL3 can activate BAP1 by increasing BAP1 's affinity specifically for the ubiquitin in the substrate, through a combination of mild effects."
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