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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TRAF6 leads to the ubiquitination of RAC1. 3 / 3

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"Mechanistically, we demonstrated that TRAF6 induced Rac1 activation and consequently promoted I/R injury by directly binding and ubiquitinating Rac1."

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"In addition, the Rac1 inhibitor (NSC23766) diminished the ubiquitination of Rac1 by coexpressed TRAF6 ( xref )."

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"These data indicate that the tight interaction of TRAF6 and inactive Rac1 is likely due to inefficient ubiquitination of inactive Rac1 by TRAF6."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...