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SPP1 binds CD4 and PI3-kinase. 1 / 1

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"Here we report that activation of ICOS in CD4(+) T cells promoted interaction of the p85α regulatory subunit of the signaling kinase PI(3)K and intracellular osteopontin (OPN-i), followed by translocation of OPN-i to the nucleus, its interaction with Bcl-6 and protection of Bcl-6 from ubiquitin-dependent proteasome degradation."

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IndraLab

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SPP1 binds CD4 and PI3-kinase. 1 / 1

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